MUG UG TUG

Dagmar Kratky

Kratky
Univ.-Prof. Mag. Dr.rer.nat. Dagmar Kratky

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging
Molecular Biology and Biochemistry

Medical University of Graz
Neue Stiftingtalstrasse 6/IV
8010 Graz, Austria

tel.: +43 (0)316 385 71965
e-mail: dagmar.kratky@medunigraz.at
web

 

Projects within the DK-MCD

Lysosomal lipid degradation in bone and muscle development Alena Akhmetshina

Consequences of intestinal LAL deficiency on whole body lipid metabolism

Valentina Bianco
graduated

Crosstalk of lysosomal lipid degradation in liver and adipose tissue

Ivan Bradić
graduated

Consequences of Matrix Metalloproteinase 12 deficiency in lysosomal acid
lipase deficiency

Martin Buerger

Role of lysosomal acid lipase in thermogenesis and energy metabolism

Madalina-Cristina Duta-Mare
graduated

Role of CGI-58 in macrophage function and atherosclerosis development

Madeleine Goeritzer
graduated

Consequences of defective lipolysis in the small intestine on lipid metabolism

Melanie Korbelius
graduated

Consequences of hepatocyte-specific lysosomal acid lipase deficiency on lipid
and carbohydrate metabolism

Christina Leopold
graduated

Link between triacylglycerol synthesizing enzymes and cholesterol metabolism

Vinay Sachdev
graduated

Role of lipases in leukocytes

Stefanie Schlager
graduated

Monoglyceride lipase (MGL) and its role in macrophage lipid metabolism and atherosclerosis

Nemanja Vujić
graduated
   

Research interest

Fatty acids are pivotal for life. Release of fatty acids from more complex lipids requires hydrolysis by an enzymatic process called lipolysis. Depending on the organelle and localization, we discriminate between neutral lipolysis in cytoplasmic lipid droplets and acid lipolysis in lysosomes.Our main goal is to understand the physiological function of metabolic lipases in distinct cells and organs. Transgenic mice as well as global and tissue-specific knockout mouse models are phenotypically characterized with special emphasis on lipid and energy metabolism. The group focuses on the function of the respective enzymes in isolated cells and tissues and studies the underlying signaling pathways.

 

Important recent contributions include the findings that lysosomal acid lipase (LAL) regulates VLDL synthesis and insulin sensitivity in mice and that LAL is crucial in murine brown adipose tissue to maintain thermogenesis. Due to the severe phenotype of Lal-deficient mice, the cause and consequence of LAL deficiency on specific cell and organ function is still unknown. Generation and characterization of tissue-specific Lal-deficient mouse models will help to clarify cell-specific functions of LAL and discriminate from systemic effects of LAL deficiency on lipid and energy metabolism.

 

Curriculum vitae

  1987 - 1997 Graduate Studies in Chemistry, University of Graz
  1995 - 1997 Master Thesis at the Institute of Biochemistry, University of Graz
  1997 Research Assistant at the Institute of Biochemistry, University of Graz
  1997 - 2000 PhD Thesis at the Institute of Molecular Biosciences, University of Graz
  2001 Research Assistant at the Institute of Pathology, University of Graz
  2002 - 2006 Assistant Professor at the Institute of Molecular Biology and Biochemistry, Medical University of Graz
  2006 Habilitation in Molecular Biology and Biochemistry, Institute of Molecular Biology and Biochemistry, Medical University of Graz
  2006 - 2012 Associate Professor at the Institute of Molecular Biology and Biochemistry, Medical University of Graz
  2012 Full Professor for Biochemistry at the Medical University of Graz
  2018 Vice Chair of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz
  2019 Speaker of the Special Research Program (SFB) "Lipid Hydrolysis"
     

Publications

Grants