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Scientific articles (since 2003)
(update: August 2010)
Peer reviewed original manuscripts and review articles
2010
Bernhart E, Kollroser M, Rechberger G, Reicher H, Heinemann A, Schratl P, Hallström S, Wintersperger A, Nusshold C, Devaney T, Zorn-Pauly K, Malli R, Graier W, Malle E, Sattler W. Lysophosphatidic acid receptor engagement affects the microglial proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture. Proteomics. 2010 Jan;10(1):141-58.
Rees MD, Whitelock JM, Malle E, Chuang CY, Iozzo RV, Nilasaroya A, Davies MJ. Myeloperoxidase-derived oxidants selectively disrupts the protein core of the heparan sulfate proteoglycan perlecan. Matrix Biol. 2010 Jan;29(1):63-73.
Üllen A, Fauler G, Köfeler H, PhD; Waltl S, Nusshold C, Bernhart E, Reicher H, Leis H-J, Wintersperger A, Malle E, Sattler W. Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo. Free Radic Biol Med. (2010) in press
Kennett EC, Rees MD, Malle E, Hammer A, Whitelock JM, Davies MJ. Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains. Free Radic Biol Med. 2010 Jul 15;49(2):282-293.
Nusshold C, Kollroser M, Köfeler H, Rechberger G, Reicher H, Üllen A, Bernhart E, Waltl S, Kratzer I, Hermetter A, Hackl H, Trajanoski Z, Hrzenjak A, Malle E, Sattler W. Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro. Free Radic Biol Med. 2010 Jun 15;48(12):1588-600
2009
Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W. Afamin is synthesized by cerebrovascular endothelial cells and mediates a-tocopherol transport across an in vitro model of the blood-brain barrier. J Neurochem. 2009 Feb;108(3):707-18.
Malle E, Sodin-Semrl S, Kovacevic A. Serum amyloid A: An acute-phase protein involved in tumour pathogenesis. Cell Mol Life Sci. 2009 Jan;66(1):9-26. (Review).
Rees MD, Bottle SE, Fairfull-Smith KE, Malle E, Whitelock JM, Davies MJ. Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides. Biochem J. 2009 Jun 12;421(1):79-86.
Chantepie S, Malle E, Sattler W, Chapman JM, Kontush A. HDL-particle subclasses distinct in physicochemical properties present similar intrinsic susceptibility to oxidative modification by hypochlorous acid. Arch Biochem Biophys. 2009 Jul 1;487(1):28-35.
Rensen SS, Slaats Y, Nijhuis J, Jans A, Bieghs V, Driessen A, Malle E, Greve JW, Buurman WA. Increased hepatic myeloperoxidase activity in obese subjects with non-alcoholic steatohepatitis. Am J Pathol. 2009 Oct;175(4):1473-82.
2008
Deng X, Lu J, Lehman-McKeeman LD, Malle E, Crandall D, Ganey PE, Roth RA. p38 MAPK-dependent TNF-α converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine. J Pharmacol Exp Ther. 2008 Jul326(1):144-152.
Kovacevic A, Hammer A, Stadelmeyer E, Windischhofer W, Sundl M, Ray A, Schweighofer N, Friedl G, Windhager R, Sattler W, Malle E. Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines. J Cell Biochem. 2008 Feb 15;103(3):994-1004.
Marsche G, Furtmüller PG, Obinger O, Sattler S, Malle E. Hypochlorite-modified high-density lipoprotein acts as a sink for myeloperoxidase in vitro. Cardiovasc Res 2008 Jul1;79(1):187-194.
Rauh A, Windischhofer W, Kovacevic A, DeVaney T, Huber E, Semlitsch M, Leis HJ, Sattler S, Malle E. ET-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ETB receptor-mediated Gi- and Gq-pathways and MAP kinase activation. Br J Pharmacol. 2008; May; 154(1): 13-24.
2007
Deng X, Luyendyk J, Zou W, Lu J, Malle E, Ganey P, Roth B. Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. J Pharmacol Exp Ther. 2007 Aug;322(2):852-61.
Popovic ZV, Sandhoff R, Sijmonsma TP, Kaden S, Jennemann R, Kiss E, Tone E, Autschbach F, Platt N, Malle E, Gröne HJ. Sulfated glycosphingolipid as mediator of phagocytosis: SM4s enhances apoptotic cell clearance and modulates macrophage activity. J Immunol. 2007 Nov 15;179(10):6770-82.
Kratzer I, Wernig K, Panzenboeck U, Bernhart E, Reicher H, Wronski R, Windisch M, Hammer A, Malle E, Zimmer A, Sattler W. Apolipoprotein A-I coating of protamine-oligonucleotide nanoparticles increases particle uptake and transcytosis in an in vitro model of the blood-brain barrier. J Control Release. 2007 Feb 26;117(3):301-11.
Marsche G, Weigle B, Sattler W, Malle E. Soluble RAGE blocks scavenger receptor CD36-mediated uptake of hypochlorite-modified low-density lipoprotein. FASEB J. 2007 Oct;21(12):3075-82.
Marsche G, Semlitsch M, Hammer A, Frank S, Weigle B, Demling N, Schmidt K, Windischhofer W, Waeg G, Sattler W, Malle E. Hypochlorite-modified albumin colocalizes with RAGE in the artery wall and promotes MCP-1 expression via the RAGE-Erk1/2 MAP-kinase pathway. FASEB J. 2007 Apr;21(4):1145-52.
Malle E, Furtmüller PG, Sattler W, Obinger C. Myeloperoxidase: a target for new drug development? Br J Pharmacol. 2007 Nov;152(6):838-54. (Review).
Marsche G, Frank S, Raynes JG, Kozarsky KF, Sattler W, Malle E. The lipidation status of serum amyloid A protein determines scavenger receptor class B type I-dependent cholesterol mobilization. The lipidation status of acute-phase protein serum amyloid A determines cholesterol mobilization via scavenger receptor class B, type I. Biochem J. 2007 Feb 15;402(1):117-24.
Hasegawa T, Ito Y, Wijeweera J, Liu J, Malle E, Farhood A, Waalkes MP, McCuskey RS, Jaeschke H. Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice. Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1385-95.
2006
Cover C, Liu J, Farhood A, Malle E, Waalkes MP, Bajt ML, Jaeschke H. Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):98-107.
Panzenboeck U, Kratzer I, Sovic A, Wintersperger A, Malle E, Sattler W. LXR and PPAR agonists modulate cholesterol homeostasis in cerebrovascular endothelial cells. Int J Biochem Cell Biol. 2006 Aug;38(8):1314-29.
Lakio L, Lehto M, Tuomainen AM, Jauhiainen M, Malle E, Asikainen S, Pussinen PJ. Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans. J Endotoxin Res. 2006;12(1):57-64.
Kovacevic A, Hammer A, Sundl M, Pfister B, Hrzenjak A, Ray A, Ray BK, Sattler W, Malle E. Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells. FEBS Lett. 2006 Jan 9;580(1):161-167.
Malle E, Marsche G, Arnhold J, Davies MJ. Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid. Biochim Biophys Acta. 2006 Apr;1761(4):392-415 (Review).
Malle E, Marsche G, Panzenboeck U, Sattler W. Myeloperoxidase-mediated oxidation of high-density lipoproteins: Fingerprints of newly recognized potential proatherogenic lipoproteins. Arch Biochem Biophys. 2006 Jan 15;445(2):245-55 (Review).
2005
Bräsen JH, Nieminen-Kelha M, Markmann D, Malle E, Schneider W, Neumayer HH, Budde K, Luft FC, Dragun D. Lectin-like oxidized low-density lipoprotein (LDL) receptor (LOX-1)-mediated pathway and vascular oxidative injury in older-age rat renal transplants. Kidney Int. 2005 Apr;67(4):1583-94.
Sovic A, Panzenboeck U, Wintersperger A, Kratzer I, Hammer A, Levak-Frank S, Frank S, Rader DJ, Malle E, Sattler W. Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier. J Neurochem. 2005 Jul;94(1):109-19.
Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, Marsche G, Young MF, Mihalik D, Gotte M, Malle E, Schaefer RM, Grone HJ. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest. 2005 Aug;115(8):2223-33.
Hasegawa T, Malle E, Farhood A, Jaeschke H. Generation of hypochlorite-modified proteins by neutrophils during ischemia-reperfusion injury in rat liver: attenuation by ischemic preconditioning. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G760-7.
2004
Sovic A, Balazs Z, Hrzenjak A, Reicher H, Panzenboeck U, Malle E, Sattler W. Scavenger receptor class B, type I mediates uptake of lipoprotein-associated phosphatidylcholine by primary porcine cerebrovascular endothelial cells. Neurosci Lett. 2004 Sep 16;368(1):11-4.
Balazs Z, Panzenboeck U, Hammer A, Sovic A, Quehenberger O, Malle E, Sattler W. Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model. J Neurochem. 2004 May;89(4):939-50.
Hrzenjak A, Reicher H, Wintersperger A, Steinecker-Frohnwieser B, Sedlmayr P, Schmidt H, Nakamura T, Malle E, Sattler W. Inhibition of lung carcinoma cell growth by high density lipoprotein-associated alpha-tocopheryl-succinate. Cell Mol Life Sci. 2004 Jun;61(12):1520-31.
Marsche G, Heller R, Fauler G, Kovacevic A, Nuszkowski A, Graier W, Sattler W, Malle E. 2-chlorohexadecanal derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2302-6.
Porubsky S, Schmid H, Bonrouhi M, Kretzler M, Malle E, Nelson PJ, Grone HJ. Influence of native and hypochlorite-modified low-density lipoprotein on gene expression in human proximal tubular epithelium. Am J Pathol. 2004 Jun;164(6):2175-87.
2003
Hanumegowda UM, Copple BL, Shibuya M, Malle E, Ganey PE, Roth RA. Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury. Toxicol Sci. 2003 Nov;76(1):237-46.
Wadsack C, Hammer A, Levak-Frank S, Desoye G, Kozarsky KF, Hirschmugl B, Sattler W, Malle E. Selective cholesteryl ester uptake from high density lipoprotein by human first trimester and term villous trophoblast cells. Placenta. 2003 Feb-Mar;24(2-3):131-43.
Malle E, Buch T, Gröne HJ. Myeloperoxidase in kidney disease. Kidney Int. 2003 Dec;64(6):1956-67 (Review).
Marsche G, Zimmermann R, Horiuchi S, Tandon NN, Sattler W, Malle E. Class B scavenger receptors CD36 and SR-BI are receptors for hypochlorite-modified low density lipoprotein. J Biol Chem. 2003 Nov 28;278(48):47562-70.
Venglarik CJ, Giron-Calle J, Wigley AF, Malle E, Watanabe N, Forman HJ. Hypochlorous acid alters bronchial epithelial cell membrane properties and prevention by extracellular glutathione. J Appl Physiol. 2003 Dec;95(6):2444-52.
Wadsack C, Hirschmugl B, Hammer A, Levak-Frank S, Kozarsky KF, Sattler W, Malle E. Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins. Int J Biochem Cell Biol. 2003 Apr;35(4):441-54.
Pussinen PJ, Metso J, Keva R, Hirschmugl B, Sattler W, Jauhiainen M, Malle E. Plasma phospholipid transfer protein-mediated reactions are impaired by hypochlorite-modification of high density lipoprotein. Int J Biochem Cell Biol. 2003 Feb;35(2):192-202.
Wadsack C, Hrzenjak A, Hammer A, Hirschmugl B, Levak-Frank S, Desoye G, Sattler W, Malle E. Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins. Eur J Biochem. 2003 Feb;270(3):451-62.
Relou IA, Hackeng CM, Akkerman JW, Malle E. Low-density lipoprotein and its effect on human blood platelets. Cell Mol Life Sci. 2003 May;60(5):961-71 (Review).
Egger T, Schuligoi R, Wintersperger A, Amann R, Malle E, Sattler W. Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia. Biochem J. 2003 Mar 1;370(Pt 2):459-67.
Oettl K, Höfler G, Ness GC, Sattler W, Malle E. An apparent decrease in cholesterol biosynthesis in peroxisomal-defective Chinese hamster ovary cells is related to impaired mitochondrial oxidation. Biochem Biophys Res Commun. 2003 Jun 13;305(4):957-63.
Brasen JH, Hakkinen T, Malle E, Beisiegel U, Yla-Herttuala S. Patterns of oxidized epitopes, but not NF-kappa B expression, change during atherogenesis in WHHL rabbits. Atherosclerosis. 2003 Jan;166(1):13-21.
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