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Medizinische Universität Graz

Selected Publications (2010-18)

  • Caraffini V, Perfler B, Berg JL, Uhl B, Schauer S, Kashofer K, Ghaffari-Tabrizi-Wizsy N, Strobl H, Wölfler A, Hoefler G, Sill H and Zebisch A. Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration. Blood 2018; in press: pii: blood-2017-09-804906. doi: 10.1182/blood-2017-09-804906.
  • Gaksch L, Kashofer K, Heitzer E, Quehenberger F, Daga S, Hofer S, Halbwedl I, Graf R, Krisper N, Hoefler G, Zebisch A, Sill H and Wölfler A. Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia. Am J Hematol 2018; 93(1):23-30.
  • Kashofer K, Gornicec M, Lind K, Caraffini V, Schauer S, Beham-Schmid C, Wölfler A, Hoefler G, Sill H and Zebisch A. Detection of prognostically relevant mutations and translocations in myeloid sarcoma by next generation sequencing. Leuk Lymphoma 2018; 59(2):501-4.
  • Magina KN, Pregartner G, Zebisch A, Wölfler A, Neumeister P, Greinix HT, Berghold A and Sill H. Cytarabine dose in the consolidation treatment of AML: a systematic review and meta-analysis. Blood 2017; 130(7): 946-8.
  • Elkashef SM, Lin AP, Myers J, Sill H, Jiang D, Dahia PLM, Aguiar RCT. IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation. Cancer Cell 2017; 31(5):619-620.
  • Schulz E, Sill H. The TP53 Pro72Arg SNP in de novo acute myeloid leukemia. Haematologica 2017; 102(5):e214-e215.
  • Lal R, Lind K, Heitzer E, Ulz P, Aubell K, Kashofer K, Middeke JM, Thiede C, Schulz E, Rosenberger A, Hofer S, Feilhauer B, Rinner B, Svendova V, Schimek MG, Rücker FG, Hoefler G, Döhner K, Zebisch A, Wölfler A and Sill H. Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia. Blood 2017; 129(18): 2587-91. 
  • Zebisch A, Lal R, Müller M, Lind K, Kashofer K, Girschikofsky M, Fuchs D, Wölfler A, Geigl JB, Sill H. Acute myeloid leukemia with TP53 germ line mutations. Blood. 2016 Nov 3;128(18):2270-2272.
  • Gornicec M, Wölfler A, Stanzel S, Sill H and Zebisch A. Evidence for a role of decitabine in the treatment of myeloid sarcoma. Ann Hematol 2017; 96(3): 505-6.
  • Hatzl S, Geiger O, Kuepper MK, Caraffini V, Seime T, Furlan T, Nussbaumer E, Wieser R, Pichler M, Scheideler M, Nowek K, Jongen-Lavrencic M, Quehenberger F, Wölfler A, Troppmair J, Sill H and Zebisch A. Increased expression of miR-23a mediates a loss of expression in the RAF kinase inhibitor protein RKIP. Cancer Res 2016;76(12): 3644-54.
  • Gisslinger H, Jeryczynski G, Gisslinger B, Wölfler A, Burgstaller S, Buxhofer-Ausch V, Schalling M, Krauth MT, Schiefer AI, Kornauth C, Simonitsch-Klupp I, Beham-Schmid C, Müllauer L, Thiele J. Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria. Leukemia 2016; 30:1126-32. doi: 10.1038/leu.2015.360. Epub 2015 Dec 29.
  • Sadovnik I, Hoelbl-Kovacic A, Herrmann H, Eisenwort G, Cerny-Reiterer S, Warsch W, Hoermann G, Greiner G, Blatt K, Peter B, Stefanzl G, Berger D, Bilban M, Herndlhofer S, Sill H, Sperr WR, Streubel B, Mannhalter C, Holyoake TL, Sexl V, Valent P. Identification of CD25 as STAT5-Dependent Growth-Regulator of Leukemic Stem Cells in Ph+ CML. Clin Cancer Res 2015 Nov 25. pii: clincanres.0767.2015.
  • Lin AP, Abbas S, Kim SW, Ortega M, Bouamar H, Escobedo Y, Varadarajan P, Qin Y, Sudderth J, Schulz E, Deutsch A, Mohan S, Ulz P, Neumeister P, Rakheja D, Gao X, Hinck A, Weintraub ST, DeBerardinis RJ, Sill H, Dahia PL, Aguiar RC. D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH. 2. Nat Commun 2015 Jul 16;6:7768. doi: 10.1038/ncomms8768.
  • Milewska M, Romano D, Herrero A, Guerriero ML, Birtwistle M, Quehenberger F, Hatzl S, Kholodenko BN, Segatto O, Kolch W, Zebisch A. Mitogen-inducible gene-6 mediates feedback inhibition from mutated BRAF towards the epidermal growth factor receptor and thereby limits malignant transformation. PLoS One. 2015 Jun 12;10(6):e0129859. doi: 10.1371/journal.pone.0129859. eCollection 2015.
  • Ortega M, Bhatnagar H, Lin AP, Wang L, Aster JC, Sill H, Aguiar RC. A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies. Leukemia 2015; 29:968-76. doi: 10.1038/leu.2014.302. Epub 2014 Oct 14.
  • Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, Kashofer K, Nojima S, Leitner A, Zebisch A, Wölfler A, Hofer S, Gerger A, Lax S, Beham-Schmid C, Steinke V, Heitzer E, Geigl JB, Windpassinger C, Hoefler G, Speicher MR, Boland CR, Kumanogoh A, Sill H. Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X. Nat Commun 2014 Oct 13;5:5191. doi: 10.1038/ncomms6191
  • Schulz E, Kashofer K, Heitzer E, Mhatre KN, Speicher MR, Hoefler G, Sill H. Preexisting TP53 mutation in therapy-related acute myeloid leukemia. Ann Hematol 2015; 94:527-9. doi: 10.1007/s00277-014-2191-0.
  • Heitzer E, Auer M, Gasch C, Pichler M, Ulz P, Hoffmann EM, Lax S, Waldispuehl-Geigl J, Mauermann O, Lackner C, Höfler G, Eisner F, Sill H, Samonigg H, Pantel K, Riethdorf S, Bauernhofer T, Geigl JB, Speicher MR. Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res 2013 May 15;73(10):2965-75. doi: 10.1158/0008-5472.CAN-12-4140
  • Troch M, Kiesewetter B, Willenbacher W, Willenbacher E, Zebisch A, Linkesch W, Fridrik M, Müllauer L, Greil R, Raderer M. Rituximab plus subcutaneous cladribine in patients with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue: a phase II study by the Arbeitsgemeinschaft Medikamentöse Tumortherapie. Haematologica 2013; 98:264-8. doi: 10.3324/haematol.2012.072587. Epub 2012 Sep 14.
  • Rommer A, Steinleitner K, Hackl H, Schneckenleithner C, Engelmann M, Scheideler M, Vlatkovic I, Kralovics R, Cerny-Reiterer S, Valent P, Sill H, Wieser R. Overexpression of primary microRNA 221/222 in acute myeloid leukemiaBMC Cancer 2013 Jul 29;13(1):364 (Epub ahead of print)
  • Orendi K, Emberger W, Speicher MR, Hoefler G, Sill H. Molecular cytogenetics and multiplex reverse-transcriptase polymerase chain reaction for risk stratification in acute myeloid leukemiaJ Clin Oncol 2013; 31: 2360-1
  • Fried I, Wölfler A, Quehenberger F, Höfler G, Sill H, Zebisch A. Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia. Haematologica 2012; 97:1936-7.
  • Schulz E, Valentin A, Ulz P, Beham-Schmid C, Lind K, Rupp V, Lackner H, Wölfler A, Zebisch A, Olipitz W, Geigl J, Berghold A, Speicher MR, Sill H. Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasmsJ Med Genet 2012; 49:422-8.
  • Zebisch A, Wölfler A, Fried I, Wolf O, Lind K, Bodner C, Haller M, Drasche A, Pirkebner D, Matallanas D, Rath O, Blyth K, Delwel R, Taskesen E, Quehenberger F, Kolch W, Troppmair J, Sill H. Frequent loss of RAF kinase protein inhibitor expression in acute myeloid leukemia. Leukemia 2012; 26:1842-9.
  • Fried I, Bodner C, Pichler MM, Lind K, Beham-Schmid C, Quehenberger F, Sperr WR, Linkesch W, Sill H, Wölfler A. Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia. Haematologica 2012; 97:246-50.
  • Zinke-Cerwenka W, Valentin A, Posch U, Beham-Schmid C, Groselj-Strele A, Linkesch W, Wölfler A, Sill H. Reduced-intensity allografting in patients with therapy-related myeloid neoplasms and active primary malignanciesBone Marrow Transplant 2011; 46:1540-4.
  • Pichler MM, Bodner C, Fischer C, Deutsch AJ, Hiden K, Beham-Schmid C, Linkesch W, Guelly C, Sill H, Wölfler A. Evaluation of mutations in the isocitrate dehydrogenase genes in therapy-related and secondary acute myeloid leukaemia identifies a patient with clonal evolution to IDH2 R172K homozygosity due to uniparental disomy. Br J Haematol 2011; 152:669-72.
  • Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A. Therapy-related myeloid neoplasms - pathobiology and clinical characteristics. Br J Pharmacol 2011; 162:792-805.
  • Wölfler A, Danen-van Oorschot AA, Haanstra JR, Valkhof M, Bodner C, Vroegindeweij E, van Strien P, Novak A, Cupedo T, Touw IP. Lineage-instructive functions of C/EBPalpha in multipotent hematopoietic cells and early thymic progenitors. Blood 2010; 116:4116-25.

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