Center for Microbiome Research | Zentrum für Mikrobiomforschung

Our Topic:

The Human Microbiome

 

About:

The human body is associated with trillions of microorganisms (the microbiome) which appear to have tremendous effects on health, disease, behavior and other aspects of human life. The composition of the microbiome (and thus its function) changes during the course of life, and in particular diversity-reduced microbial communities seem to be correlated with a variety of symptoms. The microbiome is capable to communicate with the human body cells and affects functions of human tissues and even brain. These projects aim to decipher the role of the human microbiome in the course of life and its association with human well-being and disease.

associated projects:
  • Immunometabolism (SFB F-83, FWF, 2021-2025)
  • The mother-microbiome-child interaction
    • PAMBA: the placental microbiome, Inflammatory diseases in pregnancy (FWF, 2020-2022)
    • TRAMIC: Transfer of anaerobic microbes from mother to child (Stadt Graz, 2019-2020, part of HMOs and perinatal microbial transfer, Jantscher-Krenn , FWF, 2019-2022)
    • The gut microbiome of premature infants
    • UMIC: Urinary and vaginal microbiome in preterm labour
  • Microbiome of the bladder (Stadt Graz, 2018)
  • Graz Study - Healthy Aging (Stadt Graz, 2017, Contribution)
  • The Nose-Brain Axis (FWF, 2017-2021)
    • OCEAN-Rest Study
    • Microbiome-marker in the saliva of tumor patients (MEFO graz, 2018-2019)
Recent publications:

Kumpitsch, C., Moissl-Eichinger, C., Pock, J., Thurnher, D. and Wolf, A., 2020. Preliminary insights into the impact of primary radiochemotherapy on the salivary microbiome in head and neck squamous cell carcinoma. Scientific reports, 10(1), pp.1-12.

Kurath-Koller, S., Neumann, C., Moissl-Eichinger, C., Kraschl, R., Kanduth, C., Hopfer, B., Pausan, M.R., Urlesberger, B. and Resch, B., 2020. Hospital Regimens Including Probiotics Guide the Individual Development of the Gut Microbiome of Very Low Birth Weight Infants in the First Two Weeks of Life. Nutrients, 12(5), p.1256.

Madhusudhan, N., Pausan, M.R., Halwachs, B., Durdević, M., Windisch, M., Kehrmann, J., Patra, V., Wolf, P., Boukamp, P., Moissl-Eichinger, C. and Cerroni, L., 2020. Molecular Profiling of Keratinocyte Skin Tumors Links Staphylococcus aureus Overabundance and Increased Human β-Defensin-2 Expression to Growth Promotion of Squamous Cell Carcinoma. Cancers, 12(3), p.541.

Pausan, M.R., Kolovetsiou-Kreiner, V., Richter, G.L., Madl, T., Giselbrecht, E., Obermayer-Pietsch, B., Weiss, E.C., Jantscher-Krenn, E. and Moissl-Eichinger, C., 2020. Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and-Independent Manner. Msystems, 5(3).

Thumann, T.A., Pferschy-Wenzig, E.M., Aziz-Kalbhenn, H., Ammar, R.M., Rabini, S., Moissl-Eichinger, C. and Bauer, R., 2020. Application of an in vitro digestion model to study the metabolic profile changes of an herbal extract combination by UHPLC-HRMS. Phytomedicine, p.153221.

Balskus, Emily P., Paul Carlson Jr, Kenya Honda, Fredrik Backhed, and Christine Moissl-Eichinger. "Translating Microbiome Research into Therapies: The Path Ahead." (2020): 20-21.

Afolayan, A.O., Ayeni, F.A., Moissl-Eichinger, C., Gorkiewicz, G., Halwachs, B. and Högenauer, C., 2019. Impact of a nomadic pastoral lifestyle on the gut microbiome in the fulani living in Nigeria. Frontiers in microbiology, 10, p.2138.

Bagga, D., Aigner, C.S., Reichert, J.L., Cecchetto, C., Fischmeister, F.P.S., Holzer, P., Moissl-Eichinger, C. and Schöpf, V., 2019. Influence of 4-week multi-strain probiotic administration on resting-state functional connectivity in healthy volunteers. European journal of nutrition, 58(5), pp.1821-1827.

Kispal, Z.F., Vajda, P., Kardos, D., Klymiuk, I., Moissl-Eichinger, C., Castellani, C., Singer, G. and Till, H., 2019. The local microbiome after pediatric bladder augmentation: intestinal segments and the native urinary bladder host similar mucosal microbiota. Journal of pediatric urology, 15(1), pp.30-e1.

Kumpitsch, C., Koskinen, K., Schöpf, V. and Moissl-Eichinger, C., 2019. The microbiome of the upper respiratory tract in health and disease. BMC biology, 17(1), p.87.

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