Center for Microbiome Research | Zentrum für Mikrobiomforschung

Medizinische Universität Graz

MIGrobeZ: Mikrobiominitiative Graz

AG Holzer

Group Leader

Univ.-Prof. Dr. Peter Holzer

Research Unit of Translational Neurogastroenterology

Institut für Experimentelle und Klinische Pharmakologie


+43 (316) 380-4500

Major areas of interest in microbiome research

Gut microbiota-gut-brain axis related to pain, emotional-affective processing and cognitive function Microbial factors (e.g., lipopolysaccharide, peptidoglycan, lipoteichoic acid a.o.) with a role in gut-brain and immune-brain communication Effects of diet-related factors on the microbiota-gut-brain axis Effects of probiotics on the microbiota-gut-brain axis Roles of gut hormones and neuropeptides in the gut microbiota-gut-brain axis

Published papers related to microbiome research

Painsipp E, Herzog H, Holzer P. Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of mice. Neuropharmacology 2008;55: 117-126

Painsipp E, Herzog H, Holzer P. Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behavior caused by immune challenge. J Psychopharmacol 2010;24:1551-1560

Painsipp E, Köfer MJ, Sinner F, Holzer P. Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment. PLoS One 2011;6:e20719

Holzer P, Reichmann F, Farzi A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides 2012;46:261-274

Painsipp E, Köfer MJ, Farzi A, Dischinger US, Sinner F, Herzog H, Holzer P. Neuropeptide Y and peptide YY protect from weight loss caused by Bacille Calmette-Guérin in mice. Br J Pharmacol 2013;170:1014-1026

Holzer P, Farzi A. Neuropeptides and the microbiota-gut-brain axis. Adv Exp Med Biol 2014;817:195-219

Farzi A, Reichmann F, Holzer P. The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour. Acta Physiol (Oxf) 2015;213:603-627

Farzi A, Reichmann F, Meinitzer A, Mayerhofer R, Jain P, Hassan AM, Fröhlich EE, Wagner K, Painsipp E, Rinner B, Holzer P. Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers. Brain Behav Immun 2015;44:106-120

Fröhlich EE, Mayerhofer R, Holzer P. Re-evaluating the hype: four bacterial metabolites under scrutiny. Eur J Microbiol Immunol 2015;in press.

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