Klinische Abteilung für Transplantationschirurgie
The major interest of our group is in performing clinical and translational studies on gut-liver interactions (gut permeability, gut microbiome), modulation of gut microbiome, bacterial products (e.g. endotoxin and related proteins, bacterial products in body fluids), albumin function, oxidative stress, cellular energy metabolism, immunobiology (neutrophil function, toll-like receptors), organ donation, organ quality and statistical and mathematical analysis of biomedical data.
As an example the FWF funded project „Probiotics in liver cirrhosis“ has started in July 2012. In this clinical study we will investigate on more than 100 patients with liver cirrhosis whether the supplementation with a multispecies probiotic is able to improve neutrophil function, gut permeability and gut microbiome composition in cirrhosis. Therefore we conduct a randomized, double-blinded placebo-controlled study. If our hypothesis holds true, the supplementation with a probiotic would be a simple and cost effective strategy for the prophylaxis of infections and might lead to a decrease in mortality. Within this project we also focus on the impact of cirrhosis and HCV infection on neutrophil granulocytes.
Our results will shed light on the cirrhosis associated immune deficiency syndrome. Further projects involve studying microbiome composition and the possibility and consequences of microbiome modulating strategies in metabolic syndrome, renal failure and sepsis.
major expertise and interest in microbiome research:
Gut microbiome in disease (liver cirrhosis, metabolic syndrome, renal failure, sepsis) Gut-liver axis Modulation of the gut microbiome