Center for Microbiome Research | Zentrum für Mikrobiomforschung

Medizinische Universität Graz

MIGrobeZ: Mikrobiominitiative Graz

AG Till

Major areas of interest in microbiome research

The functional interaction between the gut and host for special paediatric surgical diseases like necrotizing enterocolitis (NEC), Hirschsprung’s Disease (HD) or short bowel syndrome (SBS). We plan to study patients as well as animal models. Furthermore the area of (dietary) obesity versus (tumor-) cachexia shall be investigated in terms of energy harvesting and diversity of the microbiome. Microbiome, children, metagenomics, metabolome, paediatric surgery, hirschsprung, short bowel syndrome, tumorcachexia

Published papers related to microbiome research

Metaproteome analysis and molecular genetics of rat intestinal microbiota reveals section and localization resolved species distribution and enzymatic functionalities. Haange SB, Oberbach A, Schlichting N, Hugenholtz F, Smidt H, von Bergen M, Till H, Seifert J. J Proteome Res. 2012 Nov 2;11(11):5406-17. doi: 10.1021/pr3006364.

Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure.
Ferrer M, Ruiz A, Lanza F, Haange SB, Oberbach A, Till H, Bargiela R, Campoy C, Segura MT, Richter M, von Bergen M, Seifert J, Suarez A. Environ Microbiol. 2013 Jan;15(1):211-26. doi: 10.1111/j.1462-2920.2012.02845.x.

Tumor macroenvironment and metabolism. Al-Zoughbi W, Huang J, Paramasivan GS, Till H, Pichler M, Guertl-Lackner B, Hoefler G. Semin Oncol. 2014 Apr;41(2):281-95. doi: 10.1053/j.seminoncol.2014.02.005. Epub 2014 Mar 1. Review. Erratum in: Semin Oncol. 2014 Aug;41(4):e31.

Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia. Oberbach A, Neuhaus J, Inge T, Kirsch K, Schlichting N, Blüher S, Kullnick Y, Kugler J, Baumann S, Till H. Metabolism. 2014 Feb;63(2):242-9. doi: 10.1016/j

Weight loss surgery improves the metabolic status in an obese rat model but does not affect bladder fibrosis associated with high fat diet feeding. Oberbach A, Schlichting N, Heinrich M, Lehmann S, Till H, Mohr FW, Mannello F, Stolzenburg JU, Neuhaus J. Int J Obes (Lond). 2014 Aug;38(8):1061-7. doi: 10.1038/ijo.2013.199. Epub 2013 Oct 29.

Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children. Landgraf K, Rockstroh D, Wagner IV, Weise S, Tauscher R, Schwartze JT, Löffler D, Bühligen U, Wojan M, Till H, Kratzsch J, Kiess W, Blüher M, Körner A. Diabetes. 2014 Nov 12. pii: DB_140744.

Tumor-Associated Energy Homeostasis: Hepatoblastoma and Neuroblastoma Affect Glucose and Lipid Metabolism as well as Ghrelin, GLP-1, and PYY in Nude Rats. Till H, Schlichting N, Oberbach A. Eur J Pediatr Surg. 2015 Feb;25(1):128-31. doi: 10.1055/s-0034-1386640. Epub 2014 Aug 11.

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