Diagnostik & Forschungszentrum für Molekulare BioMedizin

Functional Proteomics and Metabolic Pathways

Research focus

Proteomics and Metabolomics, Lipid- and Cancer metabolism

Most exciting results
  • ATGL loss activates SRC in lung cancer cells
  • New method enabling one carbon metabolomics
Publications (corresponding authorships since 2018)
  • Tomin et al, Irreversible oxidative post-translational modifications in heart disease, Expert Rev Proteomics 2019
  • Schittmayer et al, Quantification of cellular folate species by LC-MS after stabilization by derivatization, Anal Chem 2018
  • Tomin et al, Deletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma Cells, J Prot Res 2018
  • Speziali et al, Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells, J Proteomics 2018
  • Wolf et al, Olfactory cleft proteome does not reflect olfactory performance in patients with idiopathic and postinfectious olfactory disorder: A pilot study, Sci Rep 2018
  • Tomazic et al, Comparison of tear proteome in allergic rhinoconjunctivitis patients and controls with respect to pollen season, Allergy 2018
Ongoing/Future plans
  • Metabolic switch induced by ATGL loss in cancer cells
  • Lipase profiling in clinical lung cancer samples
  • One carbon metabolism profiling of clinical lung cancer samples
  • Lipidome and proteome in fatty acid specific liver cell lipotoxicity
  • Phosphoproteome dynamics in lipolytic signaling in adipocytes
  • New activity-based probes for oxidoreductases and glucocerebrosidase
  • Determination of pollen proteome and proteases
  • Redox proteome and glutathione in failing heart
  • Redox metabolome in blood and its use as a biomarker of oxidative stress and quality marker of plasma
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