Diagnostik & Forschungszentrum für Molekulare BioMedizin

Mamma- und Gynäkopathologie

Research focus (Study leads in brackets)
  • Artificial Intelligence and Machine learning in Ovarian- and Breast Carcinoma (P. Regitnig)
  • Liquid Biopsy in Breast Cancer Patients (I. Speicher)
  • Male Breast Cancer (I. Brcic)
  • Methylation status of non-neoplastic epithelial proliferations surrounding invasive breast carcinomas (S. Jahn)
  • Micropapillary Breast Carcinoma and differential gene expression analysis (S. Jahn)
  • Cooperation with Institute for Biomechanics @ TU Graz (mechanical testing and simulation of arteries, aneurysms and heart muscle) (P. Regitnig, Ch. Viertler)
Most exciting results

Establishing AI/ML in a clinical trial/diagnostics (LYNA @Google)

Publications 2018/2019
  • O'Loughlin M, Andreu X, Bianchi S, Chemielik E, Cordoba A, Cserni G, Figueiredo P, Floris G, Foschini MP, Heikkilä P, Kulka J, Liepniece-Karele I, Regitnig P, Reiner A, Ryska A, Sapino A, Shalaby A, Stovgaard ES, Quinn C, Walsh EM, Zolota V, Glynn SA, Callagy G. Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer:a multi-institutional study. Breast Cancer Res Treat. 2018 Aug;171(1):1-9. doi:10.1007/s10549-018-4825-8. Epub 2018 May 17. PubMed PMID: 29774470.
  • Singer CF, Filipits M, Jahn SW, Abete L, Jakesz R, Greil R, Bauernhofer T, Kwasny W, Seifert M, Fitzal F, Kastner M, Schmitt M, Moinfar F, Gnant M. Stromal coexpression of uPA/PAI-1 protein predicts poor disease outcome in endocrine-treated postmenopausal patients with receptor-positive early breast cancer. Breast. 2019 Aug;46:101-107. doi: 10.1016/j.breast.2019.05.007. Epub 2019 May 3. PubMed PMID: 31132475.
  • Schwarzenbacher D, Klec C, Pasculli B, Cerk S, Rinner B, Karbiener M, Ivan C, Barbano R, Ling H, Wulf-Goldenberg A, Stanzer S, Rinnerthaler G, Stoeger H, Bauernhofer T, Haybaeck J, Hoefler G, Jahn SW, Parrella P, Calin GA, Pichler M. MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors. Breast Cancer Res. 2019 Feb 1;21(1):20. doi: 10.1186/s13058-019-1104-5. PubMed PMID: 30709367; PubMed Central PMCID: PMC6359814.
  • Suppan C, Brcic I, Tiran V, Mueller HD, Posch F, Auer M, Ercan E, Ulz P, Cote RJ, Datar RH, Dandachi N, Heitzer E, Balic M. Untargeted Assessment of Tumor Fractions in Plasma for Monitoring and Prognostication from Metastatic Breast Cancer Patients Undergoing Systemic Treatment. Cancers (Basel). 2019 Aug 14;11(8). pii: E1171. doi: 10.3390/cancers11081171. PubMed PMID: 31416207; PubMed Central PMCID: PMC6721524.
  • Sherifova S, Sommer G, Viertler C, Regitnig P, Caranasos T, Smith MA, Griffith BE, Ogden RW, Holzapfel GA. Failure properties and microstructure of healthy and aneurysmatic human thoracic aortas subjected to uniaxial extension with a focus on the media. Acta Biomater. 2019 Nov;99:443-456. doi: 10.1016/j.actbio.2019.08.038. Epub 2019 Aug 26. PubMed PMID: 31465883; PubMed Central PMCID: PMC6851440.
  • Niestrawska JA, Regitnig P, Viertler C, Cohnert TU, Babu AR, Holzapfel GA. The role of tissue remodeling in mechanics and pathogenesis of abdominal aortic aneurysms. Acta Biomater. 2019 Apr 1;88:149-161. doi:10.1016/j.actbio.2019.01.070. Epub 2019 Feb 5. PubMed PMID: 30735809.
  • Reich O, Braune G, Eppel W, Fiedler T, Graf A, Hefler L, Joura E, Kölbl H, Marth C, Pokieser W, Regitnig P, Reinthaller A, Tamussino K, Widschwendter A, Zeimet A, Kohlberger P. Joint Guideline of the OEGGG, AGO, AGK and ÖGZ on the Diagnosis and Treatment of Cervical Intraepithelial Neoplasia and Appropriate Procedures When Cytological Specimens Are Unsatisfactory. Geburtshilfe Frauenheilkd. 2018 Dec;78(12):1232-1244. doi: 0.1055/a-0764-4875. Epub 2018 Dec 14. PubMed PMID: 30651661; PubMed Central PMCID: PMC6301212.
  • Partl R, Regitnig P, Tauber G, Pötscher M, Bjelic-Radisic V, Kapp KS. Radiation-induced morphea-a rare but severe late effect of adjuvant breast irradiation : Case report and review of the literature. Strahlenther Onkol. 2018 Nov;194(11):1060-1065. doi: 10.1007/s00066-018-1336-9. Epub 2018 Jul 16. PubMed PMID: 30014236; PubMed Central PMCID: PMC6208943.
  • Sommer G, Benedikt C, Niestrawska JA, Hohenberger G, Viertler C, Regitnig P, Cohnert TU, Holzapfel GA. Mechanical response of human subclavian and iliac arteries to extension, inflation and torsion. Acta Biomater. 2018 Jul 15;75:235-252. doi: 10.1016/j.actbio.2018.05.043. Epub 2018 May 31. PubMed PMID: 29859367.
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