Diagnostik & Forschungszentrum für Molekulare BioMedizin

Translational Orthopedic Pathology

Research focus
  • Tumorheterogeneity
  • Molecular tumor profiling
Recent exciting results
  • Expanded molecular profiling of myxofibrosarcoma reveals potentially actionable targets
  • Expanding the clinical spectrum of CIC-DUX4 sarcomas
  • GNAS mutations as diagnostic tool to classify cellular myxomas
  • Challanging a dogma – KIT mutation in a naïve SDH deficient gastric GIST
Publications (selected)
  • Undifferentiated round cell sarcomas with CIC-DUX4 gene fusion: expanding the clinical spectrum. Brčić I, Brodowicz T, Cerroni L, Kashofer K, Serbanescu GL, Kasseroler MT, Amann G, Scheipl S, Szkandera J, Leithner A, Liegl-Atzwanger B. Pathology. 2020 Feb;52(2):236-242.
  • KIT mutation in a naïve succinate dehydrogenase-deficient gastric GIST.Brcic I, Kashofer K, Skone D, Liegl-Atzwanger B. Genes Chromosomes Cancer. 2019 Nov;58(11):798-803.
  • Detection of GNAS mutations in intramuscular / cellular myxomas as diagnostic tool in the classification of myxoid soft tissue tumors. Sunitsch S, Gilg MM, Kashofer K, Gollowitsch F, Leithner A, Liegl-Atzwanger B. Diagn Pathol. 2018 Aug 15;13(1):52.
  • Expanded molecular profiling of myxofibrosarcoma reveals potentially actionable targets. Heitzer E, Sunitsch S, Gilg MM, Lohberger B, Rinner B, Kashofer K, Stündl N, Ulz P, Szkandera J, Leithner A, Liegl-Atzwanger B Mod Pathol. 2017 Dec;30(12):1698-1709
Ongoing/Future plans
  • Epigenetics in Myxofibrosarcoma
  • Low grade fibromyxoid Sarcomas
  • Sarcoma immunenviroment
  • Searching for treatment targets in Sarcomas
  • Sarcoma database
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