Diagnostik & Forschungszentrum für Molekulare BioMedizin

Tumor pathology and molecular impact on prognosis and therapy - Dermatooncology

Research focus

Melanoma and non-melanoma skin tumor biology, clinical relevance of tumor genetics and tumor microenvironment (prognosis, therapy response, metastases at special sites…)

List of current projects
  • Chemokine-receptors in cutaneous melanoma with brain metastases: Ehall B.
  • Chemokine-receptors in ocular melanoma with liver metastases: Köller M.
  • Clinical relevance of chemokine receptors in brain metastases of carcinomas: Leoni M.
  • Chemokine receptors in Merkel cell carcinoma: Sygulla S.
  • A retrospective study to evaluate the utility of liquid biopsies in patients with metastatic melanoma: Berger M., Kashofer K.
  • A prospective study to evaluate the utility of liquid biopsies in patients with metastatic melanoma: Berger M., Kashofer K.
Future plans
  • A prospective study (approx. 130 samples) to evaluate the utility of liquid biopsies in patients with metastatic melanoma
  • TML: validation cohort
  • Chemokine receptors in metastastic melanoma in special sites - influence of immunotherapy
Most exciting results
  • Evaluating the Tumor Mutation Load (TML) im melanoma via NGS
  • Liquid Biopsy in melanoma: Detection of mutation with NGS
Selected publications
  • Richtig, G; Aigelsreiter, AM; Asslaber, M; Weiland, T; Pichler, M; Eberhard, K; Sygulla, S; Schauer, S; Hoefler, G; Aigelsreiter, A; Hedgehog pathway proteins SMO and GLI expression as prognostic markers in head and neck squamous cell carcinoma. Histopathology. 2019; 75(1):118-127
  • Berger, M; Richtig, G; Kashofer, K; Aigelsreiter, A; Richtig, E; The window of opportunities for targeted therapy in BRAFwt/NRASwt/KITwt melanoma: biology and clinical implications of fusion proteins and other mutations.G Ital Dermatol Venereol. 2018; 153(3): 349-360.
  • Koller, MC; Aigelsreiter, A. Chlamydia psittaci in Ocular Adnexal MALT Lymphoma: a Possible Causative Agent in the Pathogenesis of This Disease .CURR CLIN MICROBIOL. 2018; 5(4): 261-267
  • Koeller, M; Berger, M; Eder, S; Richtig, G; Richtig, E; Pichler, M; Winter, G; Hoefler, G; Aigelsreiter, A. Is microsatellite-instability a prognostic factor in melanoma patients treated with immune-checkpoint inhibitors? VIRCHOWS ARCH. 2018; 473: S9-S10. [Oral Communication]
  • Richtig, G; Richtig, E; Kashofer, K; Koch, L; Winter, G; Hoefler, G; Pichler, M; Ehall, B; Grübler, MR; Heinemann, A; Aigelsreiter, A. Testing and clinical implications for non-V600 BRAF mutations in metastatic NRASmt melanoma. Br J Dermatol. 2017; 177(3):860-861
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