PI: Gunther Marsche
Focus: The main research interest of my research team is to understand the role of high density lipoproteins (HDL) in inflammatory diseases. Lipoproteins are primarily known for their ability to deliver nutrients, but HDL also interacts with immune cells, macrophages, and endothelial cells - key players in both the innate and adaptive immune systems. HDL supports bacterial toxin clearance, promotes steroid synthesis, and increases the endothelial barrier through antioxidant/anti-inflammatory activities. We seek to understand why HDL may lose its protective effects in inflammatory diseases. To this end, we are studying the complex composition of HDL and measuring its diverse functionalities.
Network: We have collaborations with the Division of Physiological Chemistry (Gerhard Cvirn), the Division of Physiology (Nandu Goswami), the Division of Immunology and Pathophysiology (Sandra Holasek), the Division of Molecular Biology and Biochemistry (Sasa Frank), the Division of Gastroenterology and Hepatology (Rudolf Stauber und Vanessa Stadlbauer-Köllner), the Department of Internal Medicine (Philipp Eller), the Department of Dermatology and Venereology (Peter Wolf) and the Department of Obstetrics and Gynaecology (Christian Wadsack).