Andreas PROKESCH’s main interest lies in transcription factor networks as interface between nutrient signals and the regulation of metabolic homeostasis, dysregulation of which can lead to diseases like obesity, diabetes, and cardiovascular disorders. Current projects focus on the role of the tumor suppressor p53 as regulator of metabolic flexibility, the ability of an organism to dynamically adapt to varying nutrient stresses. In particular, the involvement of p53 in the process of fasting is scrutinized in ongoing and future projects. To investigate this on a cellular and an organismal level the lab employs approaches including gain- and loss-of-function methods in cultured cells, tissue-specific inducible mouse models, and a variety of omics methods coupled to next generation sequencing (e.g. RNA-seq, ChIP-seq) and mass spectrometry.