PI: Wolfgang Graier
Focus: The main research focus is on the regulation and function of cellular calcium homeostasis under physiological and pathophysiological conditions. Thereby, the group investigates the mechanism of mitochondrial calcium homeostasis and its impact on mitochondrial function in cancer cells and during aging. Genetically encoded biosensors are used to follow cellular signaling by fluorescence microscopy in real-time. Moreover, confocal microscopy and super-resolution microscopy (N-SIM) are used to analyze structural alterations of organelles and their interaction sites.
Network: Internationally we cooperate with Hiromi Imamura (Kyoto University, Japan), Jesse Hay (University of Montana, USA), Nikolaus Plesnila (Klinikum der Universität München, Germany), Thomas Simmen (Department of Cell Biology, University of Alberta, Canada). Our cooperation partners at the Med Uni Graz are: Klaus Groschner,Dagmar Kratky, Tobias Madl und Roland Malli (all Gottfried Schatz Research Center).