Lipid Hydrolysis

Publications that represent a collaboration of network members in different teams are marked with an asterisk. Names of Principal Investigators and Co-opted Principle Investigators are underlined (________), contributors to the platforms are indicated with a dotted underline (_ _ _ _ _ _).

Publications 2021

Vujić N, Bradić I, Goeritzer M, Kuentzel KB, Rainer S, Kratky D, Radović B. ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages. Autophagy. 2021 Jan 18:1-6. doi: 10.1080/15548627.2021.1874132.

Brejchova K, Radner FPW, Balas L, Paluchova V, Cajka T, Chodounska H, Kudova E, Schratter M, Schreiber R, Durand T, Zechner R, Kuda O. Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides. Proc Natl Acad Sci U S A. 2021 Jan;118(2):e2020999118. doi: 10.1073/pnas.2020999118.

Schilcher I, Stadler JT, Lechleitner M, Hrzenjak A, Berghold A, Pregartner G, Lhomme M, Holzer M, Korbelius M, Reichmann F, Springer A, Wadsack C, Madl T, Kratky D, Kontush A, Marsche G, Frank S. Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL. Int. J. Mol. Sci. 2021, 22, 719. doi.org/10.3390/ijms22020719

Galhuber M, Kupper N, Dohr G, Gauster M, Kwapiszewska G, Olschewski A, Jandl K, Gschwandtner E, Schweiger M, Kratky D, Leitinger G, Prokesch A, Kolb D. Histochem Cell Biol. Simple method of thawing cryo-stored samples preserves ultrastructural features in electron microscopy. 2021 Jan 6. doi: 10.1007/s00418-020-01952-z. Online ahead of print. PMID: 33404705

Publications 2020

Wunderling K, Leopold C, Jamitzky I, Yaghmour M, Zink F, Kratky D, Thiele C. Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir. Mol Metab. 2020:101150. doi: 10.1016/j.molmet.2020.101150.

* Schittmayer, M; Vujic, N; Darnhofer, B; Korbelius, M; Honeder, S; Kratky D; Birner-Gruenberger R. Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases. Mol Cell Proteomics. 2020 Dec;19(12):2104-2114. doi: 10.1074/mcp.RA120.002171.

*Xie H, Heier C, Kien B, Vesely PW, Tang Z, Sexl V, Schoiswohl G, Strießnig-Bina I, Hoefler G, Zechner R, Schweiger M. Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Sep; 1865(9):158737. doi:10.1016/j.bbalip.2020.158737. Epub 2020 May 11. PMID: 32404277 Free PMC article.

Vujic N, Korbelius M, Sachdev V, Rainer S, Zimmer A, Huber A, Radovic B, Kratky D. Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden. Atherosclerosis. 2020 Aug 10; 310:26-36. doi: 10.1016/j.atherosclerosis.2020.07.030.

*Wagner C, Hois V, Pajed L, Pusch LM, Wolinski H, Trauner M, Zimmermann R, Taschler U, Lass A. Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Aug;1865(8):158730. doi: 10.1016/j.bbalip.2020.158730. Epub 2020 May 1. PMID: 32361002 Free PMC article.

*Tardelli M, Bruschi FV, Claudel T, Fuchs CD, Auer N, Kunczer V, Stojakovic T, Scharnagl H, Habib A, Grabner GF, Zimmermann R, Lotersztajn S, Trauner M. Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption. J Lipid Res. 2019 Jul;60(7):1284-1292. doi: 10.1194/jlr.M093369. Epub 2019 May 2. PMID: 31048404 Free PMC article.

Olivieri O, Speziali G, Castagna A, Pattini P, Udali S, Pizzolo F, Liesinger L, Gindlhuber J, Tomin T, Schittmayer M, Birner-Gruenberger R, Cecconi D, Girelli D, Friso S, Martinelli N. The Positive Association between Plasma Myristic Acid and ApoCIII Concentrations in Cardiovascular Disease Patients Is Supported by the Effects of Myristic Acid in HepG2 Cells. J Nutr. 2020 Jul:nxaa202. doi: 10.1093/jn/nxaa202. Online ahead of print. PMID: 32710763

*Grabner GF, Fawzy N, Schreiber R, Pusch LM, Bulfon D, Koefeler H, Eichmann TO, Lass A, Schweiger M, Marsche G, Schoiswohl G, Taschler U, Zimmermann R. Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice. J Lipid Res. 2020 Jul;61(7):995-1003. doi: 10.1194/jlr.RA119000516. Epub 2020 Apr 29. PMID: 32350080 Free PMC article.

Fuchs CD, Krivanec S, Steinacher D, Mlitz V, Wahlström A, Stahlman M, Claudel T, Scharnagl H, Stojakovic T, Marschall HU, Trauner M. Absence of Bsep/Abcb11 attenuates MCD-diet induced hepatic steatosis but aggravates inflammation in mice. Liver Int. 2020 Jun;40(6):1366-1377. doi: 10.1111/liv.14423. Epub 2020 Mar 18. PubMed PMID: 32141703.

*Hofer P, Taschler U, Schreiber R, Kotzbeck P, Schoiswohl G. The Lipolysome-A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation.  Metabolites. 2020 Apr 10;10(4):147. doi: 10.3390/metabo10040147. PMID: 32290093 Free PMC article. Review.

Radulović S, Gottschalk B, Hörl G, Zardoya-Laguardia P, Schilcher I, Hallström S, Vujić N, Schmidt K, Trieb M, Graier WF, Malli R, Kratky D, Marsche G, Frank S. Endothelial lipase increases eNOS activating capacity of high-density lipoprotein. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158612. doi: 10.1016/j.bbalip.2020.158612. Epub 2020 Jan 7. PubMed PMID: 31923467.

Bruschi FV, Tardelli M, Herac M, Claudel T, Trauner M. Metabolic regulation of hepatic PNPLA3 expression and severity of liver fibrosis in patients with NASH. Liver Int. 2020 Feb 11. doi: 10.1111/liv.14402. [Epub ahead of print] PubMed PMID: 32043752.

Tomin T, Schittmayer M, Birner-Gruenberger R. Addressing Glutathione Redox Status in Clinical Samples by Two-Step Alkylation with N-ethylmaleimide Isotopologues. Metabolites. 2020 Feb;10(2):71. doi: 10.3390/metabo10020071. PMID: 32079090 Free PMC article.

Wallner M, Eaton DM, Berretta RM, Liesinger L, Schittmayer M, Gindlhuber J, Wu J, Jeong MY, Lin YH, Borghetti G, Baker ST, Zhao H, Pfleger J, Blass S, Rainer PP, von Lewinski D, Bugger H, Mohsin S, Graier WF, Zirlik A, McKinsey TA, Birner-Gruenberger R, Wolfson MR, Houser SR. HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction. Sci Transl Med. 2020 Jan;12(525):eaay7205. doi: 10.1126/scitranslmed.aay7205. PMID: 31915304 Free PMC article.

Publications 2019

*Tardelli M, Bruschi FV, Fuchs CD, Claudel T, Auer N, Kunczer V, Baumgartner M, A H O Ronda O, Verkade HJ, Stojakovic T, Scharnagl H, Habib A, Zimmermann R, Lotersztajn S, Trauner M. Monoacylglycerol Lipase Inhibition Protects From Liver Injury in Mouse Models of Sclerosing Cholangitis. Hepatology. 2019. doi: 10.1002/hep.30929. [Epub ahead of print] PubMed PMID: 31505038.

*Jebessa ZH, Shanmukha Kumar D, Dewenter M, Lehmann LH, Xu C, Schreiter F, Siede D, Gong XM, Worst BC, Federico G, Sauer SW, Fischer T, Wechselberger L, Müller OJ, Sossalla S, Dieterich C, Most P, Gröne HJ, Moro C, Oberer M, Haemmerle G, Katus HA, Tyedmers J, Backs J. The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. Nat Metab. 2019;1(11):1157-1167. doi: 10.1038/s42255-019-0138-4. PubMed PMID: 31742248; PubMed Central PMCID: PMC6861130.

Korbelius M, Vujic N, Sachdev V, Obrowsky S, Rainer S, Gottschalk B, Graier WF, Kratky D. ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes. Cell Rep. 2019;28(7):1923-1934.e4. doi:10.1016/j.celrep.2019.07.030. PubMed PMID: 31412256.

Bruschi FV, Claudel T, Tardelli M, Starlinger P, Marra F, Trauner M. PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells. Hepatol Commun. 2019 Jul 15;3(9):1191-1204. doi: 10.1002/hep4.1395. eCollection 2019 Sep. PubMed PMID: 31497741; PubMed Central PMCID: PMC6719741.

*Tardelli M, Bruschi FV, Claudel T, Fuchs CD, Auer N, Kunczer V, Stojakovic T, Scharnagl H, Habib A, Grabner GF, Zimmermann R, Lotersztajn S, Trauner M. Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption. J Lipid Res. 2019. 60(7):1284-1292. doi: 10.1194/jlr.M093369. Epub 2019 May 2. PubMed PMID:31048404; PubMed Central PMCID: PMC6602129.

Kulminskaya N, Oberer M. Protein-protein interactions regulate the activity of Adipose Triglyceride Lipase in intracellular lipolysis. Biochimie. 2019; pii: S0300-9084(19)30236-6. doi: 10.1016/j.biochi.2019.08.004. [Epub ahead of print] PubMed PMID: 31404588.

Tomin T, Schittmayer M, Honeder S, Heininger C, Birner-Gruenberger R. Irreversible oxidative post-translational modifications in heart disease. Expert Rev Proteomics. 2019:1-13. doi: 10.1080/14789450.2019.1645602. [Epub ahead of print] PubMed PMID: 31361162.

 

 

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