Studies on the therapeutic mechanisms of dithranol treatment in plaque-type psoriasis
In recent years, not much innovation has occurred for topical treatment options for patients with psoriasis. Although dithranol (anthralin) has been used as a topical treatment for plaque-type psoriasis for many years, its exact mechanism of action has remained largely unknown. Thus, the aim of this project is to unravel dithranol’s therapeutic mechanisms and to possibly uncover new targets for topical treatment of psoriasis. Our work so far revealed that dithranol exerts its anti-psoriatic effects by directly targeting keratinocytes and their crosstalk with neutrophils, as well as disrupting the IL-36 inflammatory loop.
