MUG UG TUG

Ruth Birner-Gruenberger

Assoc.Prof. PD DI Dr.tech. Ruth Birner-Gruenberger

Diagnostic and Research Institute of Pathology & Omics Center Graz
Medical University of Graz
Center of Medical Research (ZMF)
Stiftingtalstrasse 24
8010 Graz, Austria

tel.: +43 (0)316 385 72962
e-mail: ruth.birner-gruenberger@medunigraz.at
web

 

Projects within the DK-MCD

Functional proteomics and metabolomics for the study of
cancer metabolism
Katarina Fritz
graduated

Fatty acid species-dependent hepatic cellular lipotoxicity

Juergen Gindlhuber

Hormonal regulation of lipolysis by phosporylations

Petra Krenn

Regulation of intracellular lipid storage and mobilization

Anita Sahu-Osen
graduated

Lipid storage and mobilisation in liver disease

Maximilan Schinagl

Role of adipose triglyceride lipase (ATGL) in cancer metabolism

Tamara Tomin
graduated

Discovery of polyesterases using proteomics

Pål William Wallace
graduated
   

Research interest

Our group investigates lipid metabolism using proteomics and metabolomics for the study of lipolysis and the interplay of metabolic pathways and organelles in regulation of fatty acid and energy homeostasis in health, cancer and lipid-associated diseases. We develop tools and workflows to enable discovery and analysis of enzymes, metabolites, improve data analysis, and assess high-resolution mass spectrometer performance.

Our DK-MCD-students focus on the dissection of posttranslational regulation of intracellular lipolysis by different stimuli, such as starvation, exercise or cold exposure in white and brown adipocytes employing global phosphoproteomics approaches. In addition, they investigate ATGL-dependent and -independent roles of CGI-58/ABHD5 in cancer. Based on current result, the students analyze the molecular (phospho)proteomic, metabolic, and lipid signaling networks related to lipolysis and fatty acid metabolism to understand the (dys)regulation of lipid metabolism in health, cancer, and lipid-associated diseases.

 

Curriculum vitae

  1991 - 1998 Studies of Chemistry and Biochemistry at the Graz University of Technology
  1996 - 1997 Master Thesis at the Royal Melbourne Institute of Technology (RMIT), Melbourne, Australia
  1997 Equivalent of a first class Bachelor Honours degree (high distinction), Applied Science, Royal Melbourne Institute of Technology (RMIT), Melbourne, Australia
  1998 Dipl.-Ing. (MSc, high distinction), Chemistry, Graz University of Technology
  1998 - 2002 PhD Thesis at the Department of Biochemistry, Graz University of Technology
  1998 EMBO practical course: Membrane lipids: Organization, dynamics and interaction with proteins, Utrecht, The Netherlands
  1999 FEBS advanced course: Yeast Lipids: Metabolism and intracellular transport, Utrecht, The Netherlands
  2001 - 2003 Assistant Professor at the Department of Biochemistry, Graz University of Technology
  2002 Dr. techn. (PhD, high distinction), Chemistry, Graz University of Technology
  2003 Courses: Separation sciences and Mass spectrometry for proteomics, Geneva proteomics centre, Switzerland
  2003 - 2007 Postdoctoral fellow at the Institute of Biochemistry, Graz University of Technology
  2007 Habilitation in Biochemistry, Institute of Molecular Biology and Biochemistry, Medical University of Graz
  2007 - 2011 Director, Mass Spectrometry Core Facility, Center of Medical Research (ZMF), Medical University of Graz
  2009 - Key Researcher, Austrian Center of Biotechnology (ACIB)
  2010 Erasmus staff training in quantitative phosphoproteomics, The Netherlands Proteomics Centre, University of Utrecht, The Netherlands
  2011 - Associate Professor, Institute of Pathology, Medical University of Graz
  2012 Research training in protein arrays, Technology Research Group, Babraham Institute, Cambridge, UK
  2013 - Head of Omics Center Graz, BioTechMed-Graz, Austria
  2015 - President Austrian Proteomics and Metabolomics Association (AuPA)
  2015 Computational Proteomics summer school, Max-Plank Institute Martinsried, Germany
  2016 - Board Member Deutsche Gesellschaft für Fettwissenschaft (DGF)
  2016 Visiting Professor, Institute of Molecular Systems Biology and Institute of Health Sciences and Technologies, ETH Zürich, Switzerland
  2017 Computational Proteomics winter school, Semmering, Austria
  2017 Visiting Professor, Institute of Nutrition and Toxicology, UC Berkeley, California
  2017 DIA (Data Independent Acquisition) course, ETH Zürich, Switzerland
  2017 - General Council Member Human Proteome Organisation (HUPO)
  2018 - Head of the Bruker Center of Excellence for Life Science Mass Spectrometry
  2018 Visiting Professor, University of Witwatersrand, Johannesburg, South Africa
  2019 - Full Professor for Bioanalytics, Vienna University of Technology, Austria
     

Publications

Grants