Metabolic and Cardiovascular Disease (DK-MCD)
The DK-MCD offers an excellence PhD program that provides an in-depth, multidisciplinary training in biomedical research in a stimulating international environment. The thesis projects focus on aspects of metabolic and cardiovascular diseases that integrate basic research and clinically-oriented sciences utilizing a wide spectrum of state-of-the-art techniques.
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News 17.07.2025 14.07.2025 |
Latest Publications Hoehlschen J, Gosset É, Hofreither D, Jahnel S, Mendjan S, Schittmayer M, Tomin T, Birner-Gruenberger R. Heart saver: Comprehensive investigation of (redox-) proteomic and thiol metabolite changes induced by Cana-, Dapa-, Empagliflozin treatment in 2D and 3D heart cell models reveals increased mitochondrial activity and glutathione redox defense and involvement of redox signaling. Life Sci. 2025; 380:123923 Panzitt K, Jungwirth E, Vosko LE, Madreiter-Sokolowski CT, Madl T, Tawfik I, Habisch H, Krstic J, Prokesch A, Karitnig R, Sucher R, Erdogan CY, Vallim TA, Trauner M, Fickert P, Al-Dury S, Molinaro A, Moore DD, Thallinger GG, Marschall HU, Wagner M. FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity. Sci Transl Med. 2025; 17(811):eadn4558 Krivic D, Panasiuk O, Pilic J, Malli R, Bacsa B, Curcic S, Groschner K. Photopharmacology reveals high-specificity linkage of Ca2+ entry at TRPC6 nanodomains to NFAT activation in mast cells. Front Immunol. 2025; 16:1595036 Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, de Keizer PLJ, Burgering BMT, Sánchez-Murcia PA, Madl T. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. Nat Commun. 2025; 16(1):5672 |