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Hoehlschen J, Gosset É, Hofreither D, Jahnel S, Mendjan S, Schittmayer M, Tomin T, Birner-Gruenberger R. Heart saver: Comprehensive investigation of (redox-) proteomic and thiol metabolite changes induced by Cana-, Dapa-, Empagliflozin treatment in 2D and 3D heart cell models reveals increased mitochondrial activity and glutathione redox defense and involvement of redox signaling. Life Sci. 2025; 380:123923 doi: 10.1016/j.lfs.2025.123923 Panzitt K, Jungwirth E, Vosko LE, Madreiter-Sokolowski CT, Madl T, Tawfik I, Habisch H, Krstic J, Prokesch A, Karitnig R, Sucher R, Erdogan CY, Vallim TA, Trauner M, Fickert P, Al-Dury S, Molinaro A, Moore DD, Thallinger GG, Marschall HU, Wagner M. FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity. Sci Transl Med. 2025; 17(811):eadn4558 doi: 10.1126/scitranslmed.adn4558 Krivic D, Panasiuk O, Pilic J, Malli R, Bacsa B, Curcic S, Groschner K. Photopharmacology reveals high-specificity linkage of Ca2+ entry at TRPC6 nanodomains to NFAT activation in mast cells. Front Immunol. 2025; 16:1595036 doi: 10.3389/fimmu.2025.1595036 Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, de Keizer PLJ, Burgering BMT, Sánchez-Murcia PA, Madl T. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. Nat Commun. 2025; 16(1):5672 doi: 10.1038/s41467-025-60844-9 Tomin T, Honeder SE, Liesinger L, Gremel D, Retzl B, Lindenmann J, Brcic L, Schittmayer M, Birner-Gruenberger R. Increased antioxidative defense and reduced advanced glycation end-product formation by metabolic adaptation in non-small-cell-lung-cancer patients. Nat Commun. 2025; 16(1):5157 doi: 10.1038/s41467-025-60326-y Zhou Q, Sagmeister T, Hutten S, Bourgeois B, Pavkov-Keller T, Dormann D, Madl T. Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3. Zhou Q, Sagmeister T, Hutten S, Bourgeois B, Pavkov-Keller T, Dormann D, Madl T. Nat Commun. 2025; 16(1):4456 doi: 10.1038/s41467-025-59802-2 Oflaz FE, Bondarenko AI, Trenker M, Waldeck-Weiermair M, Gottschalk B, Bernhart E, Koshenov Z, Radulović S, Rost R, Hirtl M, Pilic J, Karunanithi Nivedita A, Sagintayev A, Leitinger G, Brachvogel B, Summerauer S, Shoshan-Barmatz V, Malli R, Graier WF. Annexin A5 controls VDAC1-dependent mitochondrial Ca2+ homeostasis and determines cellular susceptibility to apoptosis. EMBO J. 2025; 44(12):3413-3447 doi: 10.1038/s44318-025-00454-9 Kalinová K, Gottschalk B, Hirtl M, Ostaku J, Gabrijelčič S, Sokolowski A, Malle E, Graier WF, Madreiter-Sokolowski CT. Targeting enhanced mitochondrial respiration chain activity as a potential therapeutic approach for endometriosis. Biochim Biophys Acta Mol Basis Dis. 2025; 1871(6):167885 doi: 10.1016/j.bbadis.2025.167885 Peña de la Sancha P, Wieser BI, Schauer S, Reicher H, Sattler W, Breinbauer R, Schweiger M, Lechleitner M, Frank S, Zechner R, Kratky D, Espenshade PJ, Hoefler G, Vesely PW. Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis. Commun Biol. 2025;8(1):588 doi: 10.1038/s42003-025-08002-1 Akhmetshina A, Schooltink L, Amor M, Kuentzel KB, Rainer S, Nandy A, Habisch H, Madl T, Rendina-Ruedy E, Leithner K, Vujić N, Kratky D. Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function. BBA Adv. 2025; 7:100135 doi: 10.1016/j.bbadva.2024.100135 Hirtl M, Gottschalk B, Bachkoenig OA, Oflaz FE, Madreiter- Sokolowski C, Høydal MA, Graier WF. A novel super-resolution STED microscopy analysis approach to observe spatial MCU and MICU1 distribution dynamics in cells. Biochim Biophys Acta Mol Cell Res. 2025; 1872(3):119900 doi: 10.1016/j.bbamcr.2025.119900 Bradic I, Kuentzel KB, Pirchheim A, Rainer S, Schwarz B, Trauner M, Larsen MR, Vujic N, Kratky D. From LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism. Biochim Biophys Acta Mol Cell Biol Lipids. 2025; 1870(1):159575 doi: 10.1016/j.bbalip.2024.159575
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