MUG UG TUG

Klaus Groschner

Univ.-Prof. Mag.pharm. Dr.rer.nat. Klaus Groschner

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging
Biophysics
Medical University of Graz
Neue Stiftingtalstrasse 6/D04
8010 Graz, Austria

tel.: +43 (0)316 385 71500
e-mail: klaus.groschner@medunigraz.at
web
Biophysics Austria
BioTechMed

 

Projects within the DK-MCD

Role of TRPC3 channels in electrical remodeling and arrhythmias Bernhard Doleschal
graduated

Photopharmacological and optogenetic targeting of vascular endothelial function

Hazel Erkan

Novel concepts for therapeutic targeting of TRPC channels in tumors

Denis Krivić

Molecular determinants of selectivity and gating in TRPC3 channels

Michaela Lichtenegger
graduated

Role of TRIC channels in cardiovascular disease

Niroj Shrestha
graduated

Exploring structure-function relations in cardiovascular TRPC channels

Barbora Svobodova
graduated

Exploring the DAG-sensing machinery of TRPC channels – a step towards control of TRPC channels by light

Oleksandra Tiapko
graduated
   

Research interest

The long term research focus of our laboratory is biophysics and molecular (patho)physiology of lipid-regulated ion channels and transporters. The group aims at understanding structure-function relations in canonical (C-type) transient receptor potential (TRPC) channels and store-operated (Orai) channels with particular attention to the function of these channel complexes in native tissues and their response to environmental stress. Ongoing projects address the function of TRPC and Orai channels as sensors for lipid mediators.

 

Recently, we focused on photopharmacological and optochemogenetic approaches. This technology allows for exceptionally high spatiotemporal precision in controlling signaling molecules and is expected to provide deep insight into their function and pathophysiology. Development of lipid photoswitches in the laboratory has paved the way toward understanding lipid recognition and lipid signaling by ion channels. Innovative photopharmacological and optochemogenetic approaches are now available to investigate principles of dysregulation of and maladaptive responses mediated by TRPC channels in native tissues. DK-MCD students utilize novel molecular probes, transgenic animal models and optochemogenetic strategies for in depth investigations of the role of TRPC channels in native endothelial, immune, and cancer cells.

Our laboratory develops and employs molecular tools and experimental strategies to investigate the role of ion channels in native tissues. These approaches include utilization of dominant mutants, novel small molecule modulators, photochromic ligands and chemogenetic strategies for optical control of channel function, complemented by transgenic animal models for in vivo evaluation of (patho)physiologic and therapeutic concepts.

 

Curriculum vitae

  1984 Graduation, Master of Pharmacy (Mag. pharm.), University of Graz
  1986 Graduation, PhD (Dr. rer. nat.), University of Graz
  1984 - 1989 Research Associate, Department of Pharmacodynamics, University of Graz
  1989 - 1990 Postdoctoral Fellow, Department of Molecular and Cellular Pharmacology, University of Miami, USA
  1990 - 1997 Assistant Researcher, Department of Pharmacology and Toxicology, University of Graz
  1993 Habilitation in Pharmacology and Toxicology
  1997 - 2011 Associate Professor, Institute of Pharmaceutical Sciences/Pharmacology and Toxicology (IPW), University of Graz, Austria
  2012 - 2017 Full Professor and Director of the Institute of Biophysics, Medical University of Graz
  2018 - Chair of Biophysics, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging
     

Publications

Grants