Tobias Madl

Assoz. Prof. Mag. Dr.rer.nat. Tobias Madl

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging
Molecular Biology and Biochemistry
Medical University of Graz
Neue Stiftingtalstrass 6/6
8010 Graz, Austria

tel.: +43 (0)316 385 71972


Research interest

My scientific experience lies within structural biology, biophysics, bioinformatics, molecular biology, and metabolomics. My research group aims at understanding the basic molecular mechanisms of signal transduction, its regulation by post-translational modifications and environmental factors and mis-regulation of signal transduction in human diseases and ageing. We have developed tools for integrated structural biology, including structure calculation approaches combining NMR spectroscopy, Small-Angle Scattering and modeling, novel NMR techniques, and novel techniques for de novo structure prediction. Currently we investigate the interplay of signal transduction pathways involved in cell development, ageing, nuclear transport, and RNA biogenesis and their modifications in ageing, health and disease, such as neurodegeneration and cancer, using a combination of biophysical and structural techniques, bioinformatics, and NMR-based metabolomics.


Curriculum vitae

  1998 - 2004 Studies of Chemistry, Physics, History and Computational Sciences at the University Graz, Austria
  1999 - 2000 Laboratory assistant, Landeskrankenhaus Graz (hospital), Austria
  2002, 2004 First Diplomas within the enrolled programs (comparable to Bachelor of Science)
  2003 - 2004 Diploma thesis, Institute of Chemistry, University of Graz, Austria
  2004 - 2007 PhD thesis, University of Graz, Austria (DOC Fellowship of the ÖAW)
  2007 Postdoc in Structural Biology at the Institute of Chemistry, University of Graz, Austria
  2007 - 2010 Postdoc in integrative structural biology of protein-RNA complexes at the Department of Chemistry of the Technical University and at the Institute of Structural Biology at the Helmholtz Center Munich, Germany (Schrödinger Fellowship of the FWF, EMBO-LTF)
  2010 - 2011 PostDoc, Utrecht University, The Netherlands
  2012 APART fellow at Utrecht University, The Netherlands and University Graz, Austria
  2012 - 2016 Emmy Noether and BioSysNet research group leader, TUM Junior Fellow, Member of the CIPSM excellence cluster, Member of the Junior Scientist Program (Tenure Track), at Technical University and Helmholtz Zentrum Munich (HMGU), Germany
  2015 - Visiting Professor, Fujian Institute of Research on the Structure of Matter (FJIRSM), Chinese Academy of Sciences, Xiamen, China
  2015 - Associate Professor at the Institute of Molecular Biology and Biochemistry, Medical University Graz
  2015 - Associated Faculty Member Doctoral College Metabolic and Cardiovascular Diseases
  2016 Habilitation in Molecular Biology
  2016 - Faculty Member PhD Program Molecular Medicine
  2016 - Full Member of BioTechMed-Graz