The group is focusing on the analysis of molecular interaction networks with the aim to understand the dynamics of molecular networks underlying cellular processes related to human disease. Experimental functional genomics techniques, e.g. HTP Y2H screening, are utilized in combination with biochemical, cell biological and computational methods. The current focus of our work is on the systematic analyses of the functional impact of genetic variation (population and disease variation e.g. in cancer genomes) and post-translational protein modification (phosphorylation, methylation) on protein-protein interaction, which as universal protein function underlies cellular phenotypes. Using deep scanning mutagenesis approaches, we bridge the knowledge gap between nucleotide resolution genomics and protein resolution proteomics. Network biology offers a more comprehensive understanding of biology concomitantly improving the practice of medicine.

Curriculum vitae

Publications