Michael Trauner

Univ.-Prof. Michael Trauner

Division of Gastroenterology and Hepatology
Department of Internal Medicine III
Medical University of Vienna
Währinger Gürtel 18-20
1090 Vienna, Austria

tel.: +43 (0)1 40400 4741


Projects within the DK-MCD

High-dose ursodeoxycholic acid stimulates bile acid and cholesterol metabolism associated with lipid partitioning in morbidly obese patients Michaela Mueller

Research interest

Our group investigates the molecular mechanisms of cholestatic and fatty liver disease with a specific focus on the role of bile acids (BA) in the pathogenesis and treatment of these disorders. Previous work of the applicant has focused on the role of BA-activated nuclear receptors in the regulation of hepatobiliary transport and pathogenesis of cholestasis and resulted in several key publications and two international patents on the clinical use of side chain-shortened nor-ursodeoxycholic acid as novel treatment for metabolic liver diseases (Publication Number: WO2006119803) and atherosclerosis (European Patent 07 113 107.2). Emerging evidence suggests that BA-activated nuclear receptors such as the farnesoid X receptor may play a pivotal role in the control of hepatic lipid homeostasis and pathogenesis of non-alcoholic fatty liver disease (NAFLD). NAFLD represents an emerging health problem in Western societies due to its progression to liver cirrhosis, cancer and associated cardiovascular mortality. BA-activated nuclear receptors could therefore represent a novel therapeutic strategy for NAFLD and associated dyslipidemia and atherosclerosis.


Curriculum vitae

  1982 - 1991 University education in Medicine at the University of Graz
  1991 MD at the University of Graz
  1991 - 1994 Residency in Internal Medicine and Subspeciality Training in Gastroenterology and Hepatology, Department of Internal Medicine, University of Graz
  1994 - 1997 Postdoctoral Research Associate, Department of Internal Medicine and Liver Center, Yale University School of Medicine, New Haven, USA
  1997 - 2001 Subspeciality Training in Gastroenterology and Hepatology, Department of Internal Medicine, University of Graz
  2000 - 2005 Associate Professor of Medicine (Tenure), Medical University of Graz, Austria
  2005 - 2010 Full Professor of Medicine, Clinical and Molecular Hepatology, Medical University of Graz
  2010 - Full Professor and Head of the Division of of Gastroenterology and Hepatology, Medical University of Vienna