Frank Madeo

Univ.-Prof. Dr.rer.nat. Frank Madeo

Institute of Molecular Biosciences
University of Graz
Humboldtstraße 50
8010 Graz, Austria

tel.: +43 (0)316 380 8878


Projects within the DK-MCD

Yeast: a cellular model for hypochlorous acid-induced cell death
co-supervised together with Ernst Malle
Ali Alavian Ghavanini

Investigating the role of mitochondrial aspartate transport in cancer
cell proliferation
co-supervised together with Juliane Bogner-Strauss

Furkan Hamza Alkan


A novel platform for testing synergistic effects of anti-aging drugs

Martina Bergmann


Mechanisms underlying α-synuclein cytotoxicity

Lukas Habernig

Regulation of the N-acetylaspartate metabolism in brown adipocytes
co-supervised together with Juliane Bogner-Strauss

Katharina Huber

Metabolic anti-aging properties of flavonoids in yeast

Katharina Kainz

A screen for plant-derived compounds against Parkinson's disease

Selena Trattner

A mitochondrial view of aging in Saccharomyces cerevisiae

Cornelia Sommer-Ruck

Amyloid beta toxicity in models of Alzheimer's disease

Jelena Tadic

Research interest

Yeast has been successfully applied as a model for cell death and aging reseach. Yeast cells undergo apoptosis upon aging, oxidative stress, starvation, and expression of pro-apoptotic mammalian proteins. Programmed cell death in yeast demonstrates typical features of apoptotic cell death known from metazoans, such as nuclear fragmentation, chromatin condensation, DNA fragmentation, phosphatidylserine externalization, and membrane blebbing. Moreover, yeast contains classical cell death executors such as caspases, endonuclease G, apoptosis-inducing factor and BAX. We have recently unraveled autophagy as a major cytoprotective pathway in yeast inhibting both apoptotic and necrotic death. Moreover, we found that the natural autophagy enhancer spermidine prolongs lifespan of yeasts, flies, worms and the healthsspan of mice. Since autophagy is a relevant strategy to combat cell death during neurotoxicity, we aim to investigate the effects of spermidine on neuroprotection.


Curriculum vitae

  1987 - 1993 Studies of Biochemistry, University of Tübingen, Germany
  1994 - 1997 PhD Thesis, University of Tübingen, Germany
  1997 - 2004 Group Leader at the University of Tübingen, Germany
  2004 - Full Professor at the University of Graz