Ernst Malle

ao.Univ.-Prof. Dr.phil. Ernst Malle

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging
Molecular Biology and Biochemistry
Medical University of Graz
Neue Stiftingtalstrasse 6/6
8010 Graz, Austria

tel.: +43 (0)316 385 71948


Projects within the DK-MCD

Yeast: a cellular model for hypochlorous acid- induced cell death
co-supervised together with Frank Madeo
Ali Alavian Ghavanini

Signaling cascade in cardiomyocytes in response to HOCl-LDL

Chintan Koyani

Research interest

Myeloperoxidase (MPO) is a heme protein released into the extracellular space and phagocytic vacuoles by activated phagocytes. HOCl, a potent two-electron oxidant formed by the MPO-H2O2-halide-system in vitro and in vivo, plays an important role in the immune system. Excessive HOCl generation, however, results in tissue damage. MPO and HOCl are emerging as critical modulators of vascular injury by promoting inflammatory arterial pathology and formation of mature plaques. HOCl reacts with a wide range of biological substrates, including antioxidants, amines, sulfides, nucleotides, DNA, lipids, and lipoproteins, compounds that in turn adversely affect biological activities of various target cells.


Curriculum vitae

  1973 - 1981 Study of Chemistry/Physics/Pharmacy at the University of Graz
  1981- 1984 PhD Thesis in Medical Biochemistry at the Institute of Medical Biochemistry, University of Graz
  1985 - 1990 PostDoc/Assistant Professor at the Institute of Physiology, Institute of Pediatrics and Institute of Medical Biochemistry, University of Graz
  1990 - 1992 PostDoctoral Training at the Department of Internal Medicine, Division of Endocrinology and Metabolism, Phillips University, Marburg/Lahn, Germany
  1992 - 1995 Assistant Professor at the Institute of Medical Biochemistry, University of Graz
  1995 - 2003 Associate Professor at the Institute of Medical Biochemistry and Medical Molecular Biology, University of Graz
  2004 - Associate Professor at the Institute of Molecular Biology and Biochemistry, Medical University of Graz