Publications
2024 2023 2022 2021 2020 2019 Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K. Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21. Biochim Biophys Acta Mol Basis Dis. 2019; 1865(9):2125-37 doi: 10.1016/j.bbadis.2019.04.010
Safari Z, Monnoye M, Abuja PM, Mariadassou M, Kashofer K, Gérard P, Zatloukal K. Steatosis and gut microbiota dysbiosis induced by high fat diet are reversed by one-week chow diet administration. Nutr Res. 2019; 71:72-88 doi: 10.1016/j.nutres.2019.09.004
Klec C, Ziomek G, Pichler M, Malli R, Graier WF. Calcium Signaling in ß-cell Physiology and Pathology: A Revisit. Int J Mol Sci. 2019; 20(24):6110 doi: 10.3390/ijms20246110
Ramadani-Muja J, Gottschalk B, Pfeil K, Burgstaller S, Rauter T, Bischof H, Waldeck-Weiermair M, Bugger H, Graier WF, Malli R. Visualization of Sirtuin 4 Distribution between Mitochondria and the Nucleus, Based on Bimolecular Fluorescence Self-Complementation. Cells. 2019; 8(12):E1583 doi: 10.3390/cells8121583
Hofer DC, Zirkovits G, Pelzmann HJ, Huber K, Pessentheiner AR, Xia W, Uno K, Miyazaki T, Kon K, Tsuneki H, Pendl T, Al Zoughbi W, Madreiter-Sokolowski CT, Trausinger G, Abdellatif M, Schoiswohl G, Schreiber R, Eisenberg T, Magnes C, Sedej S, Eckhardt M, Sasahara M, Sasaoka T, Nitta A, Hoefler G, Graier WF, Kratky D, Auwerx J, Bogner-Strauss JG. N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health. FASEB J. 2019; 33(12):13808-24 doi: 10.1096/fj.201801323R
Trefely S, Liu J, Huber K, Doan MT, Jiang H, Singh J, von Krusenstiern E, Bostwick A, Xu P, Bogner-Strauss JG, Wellen KE, Snyder NW. Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism. Mol Metab. 2019; 30:61-71 doi: 10.1016/j.molmet.2019.09.004
Wu BJ, Li Y, Ong KL, Sun Y, Johns D, Barter PJ, Rye KA. The Cholesteryl Ester Transfer Protein Inhibitor, des-Fluoro-Anacetrapib, Prevents Vein Bypass-induced Neointimal Hyperplasia in New Zealand White Rabbits. Sci Rep. 2019; 9(1):16183 doi: 10.1038/s41598-019-52510-0
Madreiter-Sokolowski CT, Ramadani-Muja J, Ziomek G, Burgstaller S, Bischof H, Koshenov Z, Gottschalk B, Malli R, Graier WF. Tracking mitochondria's intra- and inter-organelle signaling. FEBS J. 2019; 286(22):4378-401 doi: 10.1111/febs.15103
Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer SJ, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O, Kroemer G. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019; 11(11):e10469 doi: 10.15252/emmm.201910469
Waldeck-Weiermair M, Gottschalk B, Madreiter-Sokolowski CT, Ramadani-Muja J, Ziomek G, Klec C, Burgstaller S, Bischof H, Depaoli MR, Eroglu E, Malli R, Graier WF. Development and Application of Sub-Mitochondrial Targeted Ca2+ Biosensors. Front Cell Neurosci. 2019; 13:449 doi: 10.3389/fncel.2019.00449
Klec C, Madreiter-Sokolowski CT, Ziomek G, Stryeck S, Sachdev V, Duta-Mare M, Gottschalk B, Depaoli MR, Rost R, Hay J, Waldeck-Weiermair M, Kratky D, Madl T, Malli R, Graier WF. Presenilin-1 Established ER-Ca2+ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose. Cell Physiol Biochem. 2019; 53(3):573-86 doi: 10.33594/000000158
Bischof H, Burgstaller S, Vujic N, Madl T, Kratky D, Graier WF, Malli R. Purification and Application of Genetically Encoded Potassium Ion Indicators for Quantification of Potassium Ion Concentrations within Biological Samples. Curr Protoc Chem Biol. 2019; 11(3):e71 doi: 10.1002/cpch.71
Stekovic S, Hofer SJ, Tripolt N, Aon MA, Royer P, Pein L, Stadler JT, Pendl T, Prietl B, Url J, Schroeder S, Tadic J, Eisenberg T, Magnes C, Stumpe M, Zuegner E, Bordag N, Riedl R, Schmidt A, Kolesnik E, Verheyen N, Springer A, Madl T, Sinner F, de Cabo R, Kroemer G, Obermayer-Pietsch B, Dengjel J, Sourij H, Pieber TR, Madeo F. Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans. Cell Metab. 2019; 30(3):462-76 doi: 10.1016/j.cmet.2020.02.011
Erratum in Cell Metab. 2020; 31(4):878-81 doi: 10.1016/j.cmet.2020.02.011Gottschalk B, Klec C, Leitinger G, Bernhart E, Rost R, Bischof H, Madreiter-Sokolowski CT, Radulovic S, Eroglu E, Sattler W, Waldeck-Weiermair M, Malli R, Graier WF. MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex. Nat Commun. 2019; 10(1):3732 doi: 10.1038/s41467-019-11692-x
Korbelius M, Vujic N, Sachdev V, Obrowsky S, Rainer S, Gottschalk B, Graier WF, Kratky D. ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes. Cell Rep. 2019; 28(7):1923-34 doi: 10.1016/j.celrep.2019.07.030
Madreiter-Sokolowski CT, Malli RM, Graier WF. Mitochondrial-Endoplasmic Reticulum Interplay: A Lifelong On-Off Relationship? Contact (Thousand Oaks). 2019; 2:2515256419861227 doi: 10.1177/2515256419861227
Tomin T, Schittmayer M, Honeder S, Heininger C, Birner-Gruenberger R. Irreversible oxidative post-translational modifications in heart disease. Expert Rev Proteomics. 2019; 16(8):681-693 doi: 10.1080/14789450.2019.1645602
Alkan HF, Bogner-Strauss JG. Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells Mol Cell Oncol. 2019; 6(5):e1536843 doi: 10.1080/23723556.2018.1536843
Gali CC, Fanaee-Danesh E, Zandl-Lang M, Albrecher NM, Tam-Amersdorfer C, Stracke A, Sachdev V, Reichmann F, Sun Y, Avdili A, Reiter M, Kratky D, Holzer P, Lass A, Kandimalla KK, Panzenboeck U. Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice. Mol Cell Neurosci. 2019; 99:103390 doi: 10.1016/j.mcn.2019.103390
Zimmermann A, Kainz K, Hofer SJ, Bauer MA, Schroeder S, Dengjel J, Pietrocola F, Kepp O, Ruckenstuhl C, Eisenberg T, Sigrist SJ, Madeo F, Carmona-Gutierrez D, Kroemer G. 4,4'-Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects. Autophagy. 2019; 1662-4 doi: 10.1080/15548627.2019.1632623
Baracco EE, Castoldi F, Durand S, Enot DP, Tadic J, Kainz K, Madeo F, Chery A, Izzo V, Maiuri MC, Pietrocola F, Kroemer G. α-Ketoglutarate inhibits autophagy Aging. 2019; 11(11):3418-31 doi: 10.18632/aging.102001
Zimmermann A, Kainz K, Hofer SJ, Bauer MA, Schroeder S, Dengjel J, Pietrocola F, Kepp O, Ruckenstuhl C, Eisenberg T, Sigrist SJ, Madeo F, Kroemer G, Carmona-Gutierrez D. Targeting GATA transcription factors - a novel strategy for anti-aging interventions? Microb Cell. 2019; 6(5):212-6 doi: 10.15698/mic2019.05.676
Fanaee-Danesh E, Gali CC, Tadic J, Zandl-Lang M, Kober A, Agujetas VR, de Dios C, Tam-Amersdorfer C, Stracke A, Albrecher NM, Manavalan APC, Reiter M, Sun Y, Colell A, Madeo F, Malle E, Panzenboeck U. Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid beta and cholesterol homeostasis in blood-brain barrier endothelial cells. Biochim Biophys Acta Mol Basis Dis. 2019; 1856(9):2224-45 doi: 10.1016/j.bbadis.2019.04.019
Wu BJ*, Sun Y*, Ong KL, Li Y, Tang S, Barter PJ, Rye KA. Apo (Apolipoprotein) A-I Protects Against Pregnancy-Induced Insulin Resistance in Rats.Arterioscler Thromb Vasc Biol. 2019; 39(6):1160-71 doi: 10.1161/ATVBAHA.118.312282 (*equal contribution)
Curcic S, Tiapko O, Groschner K. Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol Therap. 2019; 200:13-26 doi: 10.1016/j.pharmthera.2019.04.003
Burgstaller S, Bischof H, Gensch T, Stryeck S, Gottschalk B, Ramadani-Muja J, Eroglu E, Rost R, Balfanz S, Baumann A, Waldeck-Weiermair M, Hay JC, Madl T, Graier WF, Malli R. pH-Lemon, a fluorescent protein-based pH reporter for acidic compartments. ACS Sens. 2019; 4(4):883-91 doi: 10.1021/acssensors.8b01599
Klec C, Madreiter-Sokolowski CT, Stryeck S, Sachdev V, Duta-Mare M, Gottschalk B, Depaoli MR, Rost R, Hay J, Waldeck-Weiermair M, Kratky D, Madl T, Malli R, Graier WF. Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca2+ Leak Directed to Mitochondria in Pancreatic Islets and β -Cells.Cell Physiol Biochem. 2019; 52(1):57-75 doi: 10.33594/000000005
Svobodova B, Lichtenegger M, Platzer D, Di Giuroa CML, de la Cruz GG, Glasnov T, Schreibmayer W, Groschner K. A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators. Cell Calcium. 2019; 79:27-34 doi: 10.1016/j.ceca.2019.02.007
Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer S, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019; 10(1):651 doi: 10.1038/s41467-019-08555-w
Liu L, Panzitt K, Racedo S, Wagner M, Platzer W, Zaufel A, Theiler-Schwetz V, Obermayer-Pietsch B, Müller H, Höfler G, Heinemann A, Zollner G, Fickert P. Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1. Liver Int. 2019; 39(11):2112-23 doi: 10.1111/liv.14052
Tiapko O*, Shrestha N*, Lindinger S, Guedes de la Cruz G, Graziani A, Klec C, Butorac C, Graier W, Kubista H, Freichel M, Birnbaumer L, Romanin C, Glasnov TN, Groschner K. Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem. Sci. 2019; 10(9):2837-42 doi: 10.1039/c8sc05536j (*equal contribution)
Safari Z, Gérard P. The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD). Cell Mol Life Sci. 2019; 76(8):1541-58 doi: 10.1007/s00018-019-03011-w
Maresch LK, Benedikt P, Feiler U, Eder S, Zierler KA, Taschler U, Kolleritsch S, Eichmann TO, Schoiswohl G, Leopold C, Wieser BI, Lackner C, Rülicke T, van Klinken J, Kratky D, Moustafa T, Hoefler G, Haemmerle G. Intestine-specific overexpression of carboxylesterase 2c protects mice from diet-induced liver steatosis and obesity. Hepatol Commun. 2019; 3(2):227-45 doi: 10.1002/hep4.1292
Leopold C, Duta-Mare M, Sachdev V, Goeritzer M, Maresch L, Kolb D, Reicher H, Wagner B, Stojakovic T, Ruelicke T, Haemmerle G, Hoefler G, Sattler W, Kratky D. Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation. Biochim Biophys Acta. 2019; 1864(4):500-11 doi: 10.1016/j.bbalip.2019.01.007
Madreiter-Sokolowski CT, Waldeck-Weiermair M, Bourguignon MP, Villeneuve N, Gottschalk B, Klec C, Stryeck S, Radulovic S, Parichatikanond W, Frank S, Madl T, Malli R, Graier WF. Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging. Redox Biol. 2019; 20:458-66 doi: 10.1016/j.redox.2018.11.003
Huber K, Hofer DC, Trefely S, Pelzmann HJ, Madreiter-Sokolowski C, Duta-Mare M, Schlager S, Trausinger G, Stryeck S,Graier WF, Kolb D, Magnes C, Snyder NW, Prokesch A, Kratky D, Madl T, Wellen KE, Bogner-Strauss JG. N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes. Biochim Biophys Acta. 2019; 1866(3):337-48 doi: 10.1016/j.bbamcr.2018.08.017
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