DK-MCD Publications

2024

2023

Luan D, Dadpey B, Zaid J, Bridge-Comer PE, DeLuca JH, Xia W, Castle J, Reilly SM. Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling. Diabetes. 2023; 72(3):367-374. doi: 10.2337/db22-0444

Amor M, Bianco V, Buerger M, Lechleitner M, Vujic N, Dobrijevic A, Akhmetshina A, Pirchheim A, Schwarz B, Pessentheiner AR, Baumgartner F, Rampitsch K, Schauer S, Klobucar I, Degoricija V, Pregartner G, Kummer D, Svecla M, Sommer G, Kolb D, Holzapfel GA, Hoefler G, Frank S, Norata GD, Kratky D. Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice. Cardiovasc Diabetol. 2023; 22(1):327 doi: 10.1186/s12933-023-02064-3

Bianco V, Kratky D. Glycoprotein Non-Metastatic Protein B (GPNMB): The Missing Link Between Lysosomes and Obesity. Exp Clin Endocrinol Diabetes. 2023; 131(12):639-45 doi: 10.1055/a-2192-0101

Jonas K, Prinz F, Ferracin M, Krajina K, Pasculli B, Deutsch A, Madl T, Rinner B, Slaby O, Klec C, Pichler M. MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib. Breast Cancer Res. 2023; 25(1):119 doi: 10.1186/s13058-023-01716-2

Murtha LA, Hardy SA, Mabotuwana NS, Bigland MJ, Bailey T, Raguram K, Liu S, Ngo DT, Sverdlov AL, Tomin T, Birner-Gruenberger R, Hume RD, Iismaa SE, Humphreys DT, Patrick R, Chong JJH, Lee RJ, Harvey RP, Graham RM, Rainer PP, Boyle AJ. Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction. Sci Rep. 2023; 13(1):14995 doi: 10.1038/s41598-023-41894-9

Lang M, Krump C, Meshcheryakova A, Tam-Amersdorfer C, Schwarzenberger E, Passegger C, Connolly S, Mechtcheriakova D, Strobl H. Microenvironmental and cell intrinsic factors governing human cDC2 differentiation and monocyte reprogramming. Front Immunol. 2023; 14:1216352 doi: 10.3389/fimmu.2023.1216352

Bradić I, Liesinger L, Kuentzel KB, Vujić N, Trauner M, Birner-Gruenberger R, Kratky D. Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase. J Lipid Res. 2023; 64(9):100427 doi: 10.1016/j.jlr.2023.100427

Hardy SA, Liesinger L, Patrick R, Poettler M, Rech L, Gindlhuber J, Mabotuwana NS, Ashour D, Stangl V, Bigland M, Murtha LA, Starkey MR, Scherr D, Hansbro PM, Hoefler G, Campos Ramos G, Cochain C, Harvey RP, Birner-Gruenberger R, Boyle AJ, Rainer PP. Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction. JACC Basic Transl Sci. 2023; 8(12): 1539-54 doi: 10.1016/j.jacbts.2023.05.010

Babalola JA, Lang M, George M, Stracke A, Tam-Amersdorfer C, Itxaso I, Lucija D, Tadic J, Schilcher I, Loeffler T, Flunkert S, Prokesch M, Leitinger G, Lass A, Hutter-Paier B, Panzenboeck U, Hoefler G. Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain barrier dysfunction and inflammation. Brain Res. 2023; 1819:148518 doi: 10.1016/j.brainres.2023.148518

Ruggieri F, Jonas K, Ferracin M, Dengler M, Jaeger V, Pichler M. MicroRNAs as regulators of tumor metabolism. Endocr Relat Cancer. 2023; 30(8):e220267 doi: 10.1530/ERC-22-0267

Gottschalk B, Malli R, Graier WF. MICU1 deficiency alters mitochondrial morphology and cytochrome C release. Cell Calcium. 2023; 113:102765 doi: 10.1016/j.ceca.2023.102765

Bianco V, Korbelius M, Vujic N, Akhmetshina A, Amor M, Kolb D, Pirchheim A, Bradic I, Kuentzel KB, Buerger M, Schauer S, Phan HTT, Bulfon D, Hoefler G, Zimmermann R, Kratky D. Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration. Mol Metab. 2023; 73:101737 doi: 10.1016/j.molmet.2023.101737

Kolleritsch S, Pajed L, Tilp A, Hois V, Potoschnig I, Kien B, Diwoky C, Hoefler G, Schoiswohl G, Haemmerle G. Adverse cardiac remodeling augments adipose tissue β-adrenergic signaling and lipolysis counteracting diet-induced obesity. J Biol Chem. 2023; 299(6):104788 doi: 10.1016/j.jbc.2023.104788

Hoehlschen J, Hofreither D, Tomin T, Birner-Gruenberger R. Redox-driven cardioprotective effects of sodium-glucose co-transporter-2 inhibitors: comparative review. Cardiovasc Diabetol. 2023; 22(1):101 doi: 10.1186/s12933-023-01822-7

Akhmetshina A, Kratky D, Rendina-Ruedy E. Influence of Cholesterol on the Regulation of Osteoblast Function. Metabolites. 2023; 13(4):578 doi: 10.3390/metabo13040578

Chalhoub G, Jamnik A, Pajed L, Kolleritsch S, Hois V, Bagaric A, Prem D, Tilp A, Kolb D, Wolinski H, Taschler U, Züllig T, Rechberger GN, Fuchs C, Trauner M, Schoiswohl G, Haemmerle G. Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism. Mol Metab. 2023; 72:101725 doi: 10.1016/j.molmet.2023.101725

Oflaz FE, Koshenov Z, Hirtl M, Bachkoenig OA, Graier WF, Gottschalk B. Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca²⁺ uptake machinery potentiate mitochondrial uncoupling. Cell Calcium. 2023; 112:102736 doi: 10.1016/j.ceca.2023.102736

Korbelius M, Kuentzel KB, Bradic I, Vujic N, Kratky D. Recent insights into lysosomal acid lipase deficiency. Trends Mol Med. 2023; 29(6):425-438 doi: 10.1016/j.molmed.2023.03.001

Liebscher G, Vujic N, Schreiber R, Heine M, Krebiehl C, Duta-Mare M, Lamberti G, de Smet CH, Hess MW, Eichmann TO, Hölzl S, Scheja L, Heeren J, Kratky D, Huber LA. The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue. Mol Metab. 2023; 71:101705 doi: 10.1016/j.molmet.2023.101705

Maltan L, Weiß S, Najjar H, Leopold M, Lindinger S, Höglinger C, Höbarth L, Sallinger M, Grabmayr H, Berlansky S, Krivic D, Hopl V, Blaimschein A, Fahrner M, Frischauf I, Tiffner A, Derler I. Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1. Nat Commun. 2023; 14(1):1286 doi: 10.1038/s41467-023-36458-4

Berger N, van der Wel T, Hirschmugl B, Baernthaler T, Gindlhuber J, Fawzy N, Eichmann T, Birner-Gruenberger R, Zimmermann R, van der Stelt M, Wadsack C. Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta. Front Endocrinol (Lausanne). 2023; 14:1092024 doi: 10.3389/fendo.2023.1092024

Goeritzer M, Kuentzel KB, Beck S, Korbelius M, Rainer S, Bradic I, Kolb D, Mussbacher M, Schrottmaier WC, Assinger A, Schlagenhauf A, Rost R, Gottschalk B, Eichmann TO, Züllig T, Graier WF, Vujic N, Kratky D. Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice. Intl J Mol Sci. 2023; 24(4):3116 doi: 10.3390/ijms24043116

Honeder SE, Tomin T, Schinagl M, Pfleger R, Hoehlschen J, Darnhofer B, Schittmayer M, Birner-Gruenberger R. Research Advances Through Activity-Based Lipid Hydrolase Profiling. Isr J Chem. 2023; 63(3-4): e202200078 doi: 10.1002/ijch.202200078

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2024
2023
Luan D, Dadpey B, Zaid J, Bridge-Comer PE, DeLuca JH, Xia W, Castle J, Reilly SM. Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling. Diabetes. 2023; 72(3):367-374. doi: 10.2337/db22-0444 Amor M, Bianco V, Buerger M, Lechleitner M, Vujic N, Dobrijevic A, Akhmetshina A, Pirchheim A, Schwarz B, Pessentheiner AR, Baumgartner F, Rampitsch K, Schauer S, Klobucar I, Degoricija V, Pregartner G, Kummer D, Svecla M, Sommer G, Kolb D, Holzapfel GA, Hoefler G, Frank S, Norata GD, Kratky D. Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice. Cardiovasc Diabetol. 2023; 22(1):327 doi: 10.1186/s12933-023-02064-3 Bianco V, Kratky D. Glycoprotein Non-Metastatic Protein B (GPNMB): The Missing Link Between Lysosomes and Obesity. Exp Clin Endocrinol Diabetes. 2023; 131(12):639-45 doi: 10.1055/a-2192-0101 Jonas K, Prinz F, Ferracin M, Krajina K, Pasculli B, Deutsch A, Madl T, Rinner B, Slaby O, Klec C, Pichler M. MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib. Breast Cancer Res. 2023; 25(1):119 doi: 10.1186/s13058-023-01716-2 Murtha LA, Hardy SA, Mabotuwana NS, Bigland MJ, Bailey T, Raguram K, Liu S, Ngo DT, Sverdlov AL, Tomin T, Birner-Gruenberger R, Hume RD, Iismaa SE, Humphreys DT, Patrick R, Chong JJH, Lee RJ, Harvey RP, Graham RM, Rainer PP, Boyle AJ. Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction. Sci Rep. 2023; 13(1):14995 doi: 10.1038/s41598-023-41894-9 Lang M, Krump C, Meshcheryakova A, Tam-Amersdorfer C, Schwarzenberger E, Passegger C, Connolly S, Mechtcheriakova D, Strobl H. Microenvironmental and cell intrinsic factors governing human cDC2 differentiation and monocyte reprogramming. Front Immunol. 2023; 14:1216352 doi: 10.3389/fimmu.2023.1216352 Bradić I, Liesinger L, Kuentzel KB, Vujić N, Trauner M, Birner-Gruenberger R, Kratky D. Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase. J Lipid Res. 2023; 64(9):100427 doi: 10.1016/j.jlr.2023.100427 Hardy SA, Liesinger L, Patrick R, Poettler M, Rech L, Gindlhuber J, Mabotuwana NS, Ashour D, Stangl V, Bigland M, Murtha LA, Starkey MR, Scherr D, Hansbro PM, Hoefler G, Campos Ramos G, Cochain C, Harvey RP, Birner-Gruenberger R, Boyle AJ, Rainer PP. Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction. JACC Basic Transl Sci. 2023; 8(12): 1539-54 doi: 10.1016/j.jacbts.2023.05.010 Babalola JA, Lang M, George M, Stracke A, Tam-Amersdorfer C, Itxaso I, Lucija D, Tadic J, Schilcher I, Loeffler T, Flunkert S, Prokesch M, Leitinger G, Lass A, Hutter-Paier B, Panzenboeck U, Hoefler G. Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain barrier dysfunction and inflammation. Brain Res. 2023; 1819:148518 doi: 10.1016/j.brainres.2023.148518 Ruggieri F, Jonas K, Ferracin M, Dengler M, Jaeger V, Pichler M. MicroRNAs as regulators of tumor metabolism. Endocr Relat Cancer. 2023; 30(8):e220267 doi: 10.1530/ERC-22-0267 Gottschalk B, Malli R, Graier WF. MICU1 deficiency alters mitochondrial morphology and cytochrome C release. Cell Calcium. 2023; 113:102765 doi: 10.1016/j.ceca.2023.102765 Bianco V, Korbelius M, Vujic N, Akhmetshina A, Amor M, Kolb D, Pirchheim A, Bradic I, Kuentzel KB, Buerger M, Schauer S, Phan HTT, Bulfon D, Hoefler G, Zimmermann R, Kratky D. Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration. Mol Metab. 2023; 73:101737 doi: 10.1016/j.molmet.2023.101737 Kolleritsch S, Pajed L, Tilp A, Hois V, Potoschnig I, Kien B, Diwoky C, Hoefler G, Schoiswohl G, Haemmerle G. Adverse cardiac remodeling augments adipose tissue β-adrenergic signaling and lipolysis counteracting diet-induced obesity. J Biol Chem. 2023; 299(6):104788 doi: 10.1016/j.jbc.2023.104788 Hoehlschen J, Hofreither D, Tomin T, Birner-Gruenberger R. Redox-driven cardioprotective effects of sodium-glucose co-transporter-2 inhibitors: comparative review. Cardiovasc Diabetol. 2023; 22(1):101 doi: 10.1186/s12933-023-01822-7 Akhmetshina A, Kratky D, Rendina-Ruedy E. Influence of Cholesterol on the Regulation of Osteoblast Function. Metabolites. 2023; 13(4):578 doi: 10.3390/metabo13040578 Chalhoub G, Jamnik A, Pajed L, Kolleritsch S, Hois V, Bagaric A, Prem D, Tilp A, Kolb D, Wolinski H, Taschler U, Züllig T, Rechberger GN, Fuchs C, Trauner M, Schoiswohl G, Haemmerle G. Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism. Mol Metab. 2023; 72:101725 doi: 10.1016/j.molmet.2023.101725 Oflaz FE, Koshenov Z, Hirtl M, Bachkoenig OA, Graier WF, Gottschalk B. Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca²⁺ uptake machinery potentiate mitochondrial uncoupling. Cell Calcium. 2023; 112:102736 doi: 10.1016/j.ceca.2023.102736 Korbelius M, Kuentzel KB, Bradic I, Vujic N, Kratky D. Recent insights into lysosomal acid lipase deficiency. Trends Mol Med. 2023; 29(6):425-438 doi: 10.1016/j.molmed.2023.03.001 Liebscher G, Vujic N, Schreiber R, Heine M, Krebiehl C, Duta-Mare M, Lamberti G, de Smet CH, Hess MW, Eichmann TO, Hölzl S, Scheja L, Heeren J, Kratky D, Huber LA. The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue. Mol Metab. 2023; 71:101705 doi: 10.1016/j.molmet.2023.101705 Maltan L, Weiß S, Najjar H, Leopold M, Lindinger S, Höglinger C, Höbarth L, Sallinger M, Grabmayr H, Berlansky S, Krivic D, Hopl V, Blaimschein A, Fahrner M, Frischauf I, Tiffner A, Derler I. Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1. Nat Commun. 2023; 14(1):1286 doi: 10.1038/s41467-023-36458-4 Berger N, van der Wel T, Hirschmugl B, Baernthaler T, Gindlhuber J, Fawzy N, Eichmann T, Birner-Gruenberger R, Zimmermann R, van der Stelt M, Wadsack C. Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta. Front Endocrinol (Lausanne). 2023; 14:1092024 doi: 10.3389/fendo.2023.1092024 Goeritzer M, Kuentzel KB, Beck S, Korbelius M, Rainer S, Bradic I, Kolb D, Mussbacher M, Schrottmaier WC, Assinger A, Schlagenhauf A, Rost R, Gottschalk B, Eichmann TO, Züllig T, Graier WF, Vujic N, Kratky D. Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice. Intl J Mol Sci. 2023; 24(4):3116 doi: 10.3390/ijms24043116 Honeder SE, Tomin T, Schinagl M, Pfleger R, Hoehlschen J, Darnhofer B, Schittmayer M, Birner-Gruenberger R. Research Advances Through Activity-Based Lipid Hydrolase Profiling. Isr J Chem. 2023; 63(3-4): e202200078 doi: 10.1002/ijch.202200078
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