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Hofer SJ, Simon AK, Bergmann M, Eisenberg T, Kroemer G, Madeo F. Mechanisms of spermidine-induced autophagy and geroprotection. Nat Aging. 2022; 2:1112-29 doi: 10.1038/s43587-022-00322-9 Gindlhuber J, Tomin T, Wiesenhofer F, Zacharias M, Liesinger L, Demichev V, Kratochwill K, Gorkiewicz G, Schittmayer M, Birner-Gruenberger R. Proteomic profiling of end-stage COVID-19 lung biopsies. Clin Proteomics. 2022; 19(1):46 doi: 10.1186/s12014-022-09386-6 Prinz F, Jonas K, Balihodzic A, Klec C, Reicher A, Barth DA, Riedl J, Gerger A, Kiesslich T, Mayr C, Rinner B, Kargl J, Pichler M. MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response. RNA Biol. 2022; 19(1):1305-15 doi: 10.1080/15476286.2022.2152978 Truong JK, Bennett AL, Klindt C, Donepudi AC, Malla SR, Pachura KJ, Zaufel A, Moustafa T, Dawson PA, Karpen SJ. Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury. J Lipid Res. 2022; 63(9):100261 doi: 10.1016/j.jlr.2022.100261 Curcic S, Erkan-Candag H, Pilic J, Malli R, Wiedner P, Tiapko O, Groschner K. TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors. Cell Calcium. 2022; 108:102670 doi: 10.1016/j.ceca.2022.102670 Bachkoenig OA, Gottschalk B, Malli R, Graier WF. An unexpected effect of risperidone reveals a nonlinear relationship between cytosolic Ca2+ and mitochondrial Ca2+ uptake. Curr Top Membr. 2022; 90:13-35 doi: 10.1016/bs.ctm.2022.09.001 Lenard AJ, Mulder FAA, Madl T. Solvent paramagnetic relaxation enhancement as a versatile method for studying structure and dynamics of biomolecular systems. Prog Nucl Magn Reson Spectrosc. 2022; 132-133:113-39 doi: 10.1016/j.pnmrs.2022.09.001 Alderson TR, Habacher H, Bourgeois B, Madl T. The LEF-1 high-mobility group box adopts residual structure in its DNA-free form. J Magn Reson Open. 2022; 12-13:100074 doi: 10.1016/j.jmro.2022.100074 Kuentzel KB, Bradic I, Mihalic ZN, Korbelius M, Rainer S, Pirchheim A, Kargl J, Kratky D. Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice. Int J Mol Sci. 2022; 23(20):12286 doi: 10.3390/ijms232012286 Zhou Q*, Zhang F*, Kerbl-Knapp J, Korbelius M, Kuentzel KB, Vujic N, Akhmetshina A, Hörl G, Paar M, Steyrer E, Kratky D, Madl T. Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice. Biomolecules. 2022; 12(9):1270 *equal contribution doi: 10.3390/biom12091270 Gottschalk B, Koshenov Z, Bachkoenig OA, Rost R, Malli R, Graier WF. MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites. Front Cell Dev Biol. 2022; 10:918691 doi: 10.3389/fcell.2022.918691 Egger NB, Kainz K, Schulze A, Bauer MA, Madeo F, Carmona-Gutierrez D. The rise of Candida auris: from unique traits to co-infection potential. Microb Cell. 2022; 9(8):141-4 doi: 10.15698/mic2022.08.782 Gottschalk B, Koshenov Z, Waldeck-Weiermair M, Radulovic S, Oflaz FE, Hirtl M, Bachkoenig OA, Leitinger G, Malli R, Graier WF. MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures. Commun Biol. 2022; 5(1):649 doi: 10.1038/s42003-022-03606-3 Klec C, Knutsen E, Schwarzenbacher D, Jonas K, Pasculli B, Heitzer E, Rinner B, Krajina K, Prinz F, Gottschalk B, Ulz P, Deutsch A, Prokesch A, Jahn SW, Lellahi SM, Perander M, Barbano R, Graier WF, Parrella P, Calin GA, Pichler M. ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform. Cell Mol Life Sci. 2022; 79(7):391 doi: 10.1007/s00018-022-04402-2 Erkan-Candag H, Krivic D, Gsell MAF, Aleksanvan M, Stockner T, Dimova R, Tiapko O, Groschner K. Characterization of DAG Binding to TRPC Channels by Target-Dependent cis–trans Isomerization of OptoDArG. Biomolecules. 2022; 12(6):799 doi: 10.3390/biom12060799 Reinisch I, Klymiuk I, Michenthaler H, Moyschewitz E, Galhuber M, Krstic J, Domingo M, Zhang F, Karbiener M, Vujic N, Kratky D, Schreiber R, Schupp M, Lenihan-Geels G, Schulz TJ, Malli R, Madl T, Prokesch A. p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting. Front Genet. 2022; 13:913030 doi: 10.3389/fgene.2022.913030 Oflaz FE*, Koshenov Z*, Hirtl M, Rost R, Malli R, Graier WF. Sigma-1 Receptor Modulation by Ligands Coordinates Cancer Cell Energy Metabolism. Biomolecules. 2022; 12(6):762 *equal contribution doi: 10.3390/biom12060762 Erkan-Candag H*, Clarke A*, Tiapko O, Gsell MA, Stockner T, Groschner K. Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state. EMBO Rep. 2022; 23(7):e54276 *equal contribution doi: 10.15252/embr.202154276 Bradic I, Kuentzel KB, Honeder S, Grabner GF, Vujic N, Zimmermann R, Birner-Gruenberger R, Kratky D. Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases. Mol Metab. 2022; 61:101510 doi: 10.1016/j.molmet.2022.101510 Spreitzer E, Alderson R, Bourgeois B, Eggenreich L, Habacher H, Brahmersdorfer G, Pritisanac I, Sanchez-Murcia PA, Madl T. FOXO transcription factors differ in their dynamics and intra/intermolecular interactions. Curr Res Struct Biol. 2022; 4:118-33 doi: 10.1016/j.crstbi.2022.04.001 Balihodzic A, Prinz F, Dengler MA, Calin GA, Jost PJ, Pichler M. Non-coding RNAs and ferroptosis: potential implications for cancer therapy. Cell Death Differ. 2022; 29(6):1094-106 doi: 10.1038/s41418-022-00998-x Barth DA, Stanzer S, Spiegelberg JA, Bauernhofer T, Absenger G, Szkandera J, Gerger A, Smolle MA, Hutterer GC, Ahyai SA, Madl T, Posch F, Riedl JM, Klec C, Jost PJ, Kargl J, Stradner MH, Pichler M. Patterns of Peripheral Blood B-Cell Subtypes Are Associated With Treatment Response in Patients Treated With Immune Checkpoint Inhibitors: A Prospective Longitudinal Pan-Cancer Study. Front Immunol. 2022; 13:840207 doi: 10.3389/fimmu.2022.840207 Ring J, Tadic J, Ristic S, Poglitsch M, Bergmann M, Radic N, Mossmann D, Liang YT, Maglione M, Jerkovic A, Hajiraissi R, Hanke M, Küttner V, Wolinski H, Zimmermann A, Domuz Trifunovic L, Mikolasch L, Moretti DN, Broeskamp F, Westermayer J, Abraham C, Schauer S, Dammbrueck C, Hofer SJ, Mahmoud Abdellatif M, Grundmeier G, Kroemer G, Braun RJ, Hansen N, Sommer C, Ninkovic M, Seba S, Rockenfeller P, Vögtle F-N, Dengjel J, Meisinger C, Keller A, Sigrist SJ, Eisenberg T, Madeo M. The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. EMBO Mol Med. 2022; 14(5):e13952 doi: 10.15252/emmm.202113952 Kanti MM*, Striessnig-Bina I*, Wieser BI, Schauer S, Leitinger G, Eichmann TO, Schweiger M, Winkler M, Winter E, Lana A, Kufferath I, Marsh LM, Kwapiszewska G, Zechner R, Hoefler G, Vesely PW. Adipose triglyceride lipase mediated lipid catabolism is essential for bronchiolar regeneration. JCI Insight. 2022; 7(9):e149438 *equal contribution doi: 10.1172/jci.insight.149438 Tadic J, Ring J, Jerkovic A, Ristic S, Maglione M, Dengjel J, SSigrist SJ, Eisenberg T. A pathological role of the Hsp40 protein Ydj1/DnaJA1 in models of Alzheimer’s disease. Cell Stress. 2022; 6(5):61-4. doi: 10.15698/cst2022.05.267 Gindlhuber J, Schinagl M, Liesinger L, Darnhofer B, Tomin T, Schittmayer M, Birner-Gruenberger R. Hepatocyte Proteome Alterations Induced by Individual and Combinations of Common Free Fatty Acids. Int J Mol Sci. 2022, 23(6):3356 doi: 10.3390/ijms23063356 Joshi L, Plastira I, Bernhart E, Reicher H, Koshenov Z, Graier WF, Vujic N, Kratky D, Rivera R, Chun J, Sattler W. Lysophosphatidic Acid Receptor 5 (LPA5) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro. Cells. 2022; 11(7):1071 doi: 10.3390/cells11071071 Goeritzer M, Schlager S, Kuentzel KB, Vujic N, Korbelius M, Rainer S, Kolb D, Mussbacher M, Salzmann M, Schrottmaier WC, Assinger A, Schlagenhauf A, Madreiter-Sokolowski CT, Blass S, Eichmann TO, Graier WF, Kratky D. Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo. Cells. 2022; 11(5):850 doi: 10.3390/cells11050850 Lenard AJ*, Zhou Q*, Madreiter-Sokolowski C, Bourgeois B, Habacher H, Khanna Y, Madl T. EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner. Cells. 2022; 11(4):592 *equal contribution doi: 10.3390/cells11040592 Korbelius M, Vujić N, Kuentzel KB, Obrowsky S, Rainer S, Haemmerle G, Rülicke T, Kratky D. Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis. Biochim Biophys Acta Mol Cell Biol Lipids. 2022; 1867(4):15912 doi: 10.1016/j.bbalip.2022.159121 Tawfik I, Gottschalk B, Jarc A, Bresilla D, Rost R, Obermayer-Pietsch B, Graier WF, Madreiter-Sokolowski CT. T3-induced enhancement of mitochondrial Ca2+ uptake as a boost for mitochondrial metabolism. Free Radic Biol Med. 2022; 181:197-208 doi: 10.1016/j.freeradbiomed.2022.01.024 Kien B, Kolleritsch S, Kunowska N, Heier C, Chalhoub G, Tilp A, Wolinski H, Stelzl U, Haemmerle G. Lipid droplet-mitochondria coupling via Perilipin 5 augments respiratory capacity but is dispensable for FA oxidation. J Lipid Res. 2022; 63(3):100172 doi: 10.1016/j.jlr.2022.100172 Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Riahi Z, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Usluer S, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A. Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism. Sci Adv. 2022; 8(3):eabh2635 doi: 10.1126/sciadv.abh2635 Koshenov Z, Oflaz FE, Hirtl M, Gottschalk B, Rost R, Malli R, Graier WF. Citrin mediated metabolic rewiring in response to altered basal subcellular Ca2+ homeostasis. Commun Biol. 2022; 5(1):76 doi: 10.1038/s42003-022-03019-2 Zhou Q*, Kerbl-Knapp J*, Zhang F, Korbelius M, Kuentzel KB, Vujic N, Akhmetshina A, Hoerl G, Paar M, Steyrer E, Kratky D, Madl T. Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism. Metabolites. 2022; 12(1):17 *equal contribution doi: 10.3390/metabo12010017 Gottschalk B, Madreiter-Sokolowski CT, Graier WF. Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics. Cell Calcium. 2022; 101:102517 doi: 10.1016/j.ceca.2021.102517 Trefely S, Huber K, Liu J, Noji M, Stransky S, Singh J, Doan MT, Lovell CD, von Krusenstiern E, Jiang H, Bostwick A, Pepper HL, Izzo L, Zhao S, Xu JP, Bedi KC Jr, Rame JE, Bogner-Strauss JG, Mesaros C, Sidoli S, Wellen KE, Snyder NW. Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation. Mol Cell. 2022; 82(2):447-62 doi: 10.1016/j.molcel.2021.11.006
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