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Biomolecular Structures and Interactions (BioMolStruct)
Biomolecular Structures and Interactions (BioMolStruct)PhD ProgramDoktoratsstudienMed Uni Graz

Publications

2025

  • Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M,  Zhou Q, Usluer S,  De Keizer P, Burgering B,  Sánchez-Murcia P, Madl T. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. 2025, Nat Commun. DOI: https://doi.org/10.1038/s41467-025-60844-9 
  • Zhou Q. Sagmeister T, Hutten S, Bourgois B, Pavkov-Keller T, Dormann D, Madl T. (2025): Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3. 2025, Nat Commun. DOI: https://doi.org/10.1038/s41467-025-59802-2

2024

  • Wirnsberger, G.; Pritišanac, I.; Oberdorfer, G.; Gruber, K. Flattening the curve—How to get better results with small deep-mutational-scanning datasets. Proteins: Structure, Function, and Bioinformatics 2024, n/a (n/a). DOI: https://doi.org/10.1002/prot.26686
  • Myrtollari, K.; Calderini, E.; Kracher, D.; Schöngaßner, T.; Galušić, S.; Slavica, A.; Taden, A.; Mokos, D.; Schrüfer, A.; Wirnsberger, G.; et al. Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures. ACS Sustainable Chemistry & Engineering 2024, 12 (9), 3575-3584. DOI: https://doi.org/10.1021/acssuschemeng.3c06513 

  • Michaelis C*, Berger TMI*, Kuhlmann K, Ghulam R, Petrowitsch L, Besora Vecino M, Gesslbauer B, Pavkov-Keller T, Keller W, Grohmann E. Effect of TraN key residues involved in DNA binding on pIP501 transfer rates in Enterococcus faecalis. 2024, Front Mol Biosci 11:1268647. DOI: https://doi.org/10.3389/fmolb.2024.1268647  

  • Usluer S, Galhuber M, Khanna Y, Bourgeois B, Spreitzer E, Michenthaler H, ... Madl T. (2024). Disordered regions mediate the interaction of p53 and MRE11. 2024, Biochimica et biophysica acta. Molecular cell research, 1871(2), pp. 119654. DOI: https://doi.org/10.1016/j.bbamcr.2023.119654 

  • Tripp A., Braun M., Wieser F., Oberdorfer G., Lechner H. 2024, Click, Compute, Create: A Review of web-based Tools for Enzyme Engineering. ChemBioChem (under review)

  • Natalia Kulminskaya, Carlos Francisco Rodriguez Gamez, Peter Hofer, Ines Kathrin Cerk , Noopur Dubey, Roland Viertlmayr, Theo Sagmeister, Tea Pavkov-Keller, Rudolf Zechner, Monika Oberer, Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58, J Lipid Res. 2024 Jan;65(1): DOI: https://doi.org/100491.doi: 10.1016/j.jlr.2023.100491 

  • Sagmeister T, Gubensäk N, Buhlheller C, Grininger C, Eder M, Ðordić A, Millán C, Medina A, Sánchez-Murcia P, Berni F, Hynönen U, Vejzović D, Damisch E, Kulminskaya N, Petrowitsch L, Oberer M, Palva A, Malanović N, Codée J, Keller W, Usón I, Pavkov-Keller T*. The molecular architecture of Lactobacillus S-Layer: Assembly and attachment to teichoic acids. 2024, PNAS accepted. DOI: (preprint) https://doi.org/10.21203/rs.3.rs-3689109/v1 

  • Michaelis C*, Berger TMI*, Kuhlmann K, Ghulam R, Petrowitsch L, Besora Vecino M, Gesslbauer B, Pavkov-Keller T, Keller W, Grohmann E. Effect of TraN key residues involved in DNA binding on pIP501 transfer rates in Enterococcus faecalis. 2024, Front Mol Biosci 11:1268647. DOI: https://doi.org/10.3389/fmolb.2024.1268647  

  • Dynamics-driven allosteric stimulation of diguanylate cyclase activity in a red light-regulated phytochrome. Tran, Q. H., Eder, O. M. & Winkler, A., May 2024, In: The Journal of Biological Chemistry. 300, 5, 107217. 2024, https://doi.org/10.1016/j.jbc.2024.107217

  • M. Rotzinger, N. Schuster, K. Zangger, ChemPhysChem 2024, 25, e202300713.

2023

  • Zhang F, Rakhimbekova A, Lashley T, Madl T. Brain regions show different metabolic and protein arginine methylation phenotypes in frontotemporal dementias and Alzheimer’s disease. Prog Neurobiol. 2023; 221:102400. DOI: https://doi.org/10.1016/j.pneurobio.2022.102400 

  • Braun M., Gruber C. C., Krassnigg A., Kummer A., Lutz S., Oberdorfer G., Siirola E., Snajdrova R. (2023) Accelerating Biocatalysis Discovery with Machine Learning: A Paradigm Shift in Enzyme Engineering, Discovery, and Design. 2023, ACS Catal. DOI: https://doi.org/10.1021/acscatal.3c03417 

  • M. Kaltenegger, L. Percifull, T. Radanovic, J. Causemann, B. Grill, S. Keller, G. Oberdorfer, R. Ernst, and G. Pabst, Shape-based design & purification of bitopic transmembrane peptides, Europ. Biophys. J 52 (Suppl 1): S137. 2023, DOI: https://doi.org/s00249-023-01668-7 

  • Gubensak N, Sagmeister T, Buhlheller C, Geronimo BD, Wagner GE, Petrowitsch L, Grawert MA, Rotzinger M, Berger TMI, Schafer J, Uson I, Reidl J, Sanchez-Murcia PA, Zangger K, Pavkov-Keller T. Vibrio cholerae's ToxRS bile sensing system. 2023 Elife 12. DOI: https://doi.org/10.7554/eLife.88721  

2022

  • Lenard AJ, Mulder FAA, Madl T. Solvent paramag-netic relaxation enhancement as a versatile method for studying structure and dynamics of biomolecular systems. Prog Nucl Magn Reson Spectrosc. 2022;132-133:113-39. DOI: https://doi.org/10.1016/j.pnmrs.2022.09.001
  • Eisner H, Riegler-Berket L, Gamez CFR, Sagmeister T, Chalhoub G, Darnhofer B, Jazleena PJ, Birner-Gruenberger R, Pavkov-Keller T, Haemmerle G, Schoiswohl G, Oberer M. The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1. Int J Mol Sci. 2022;23:13101. DOI: https://doi.org/10.3390/ijms232113101
  • Lenard AJ, Zhou Q, Madreiter-Sokolowski C, Bourgeois B, Habacher H, Khanna Y, Madl T. EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner. Cells. 2022;11(4):592. DOI: https://doi.org/10.3390/cells11040592 

  • Berger TMI, Michaelis C, Probst I, Sagmeister T, Petrowitsch L, Puchner S, Pavkov-Keller T, Gesslbauer B, Grohmann E, Keller W. Small Things Matter: The 11.6-kDa TraB Protein is Crucial for Antibiotic Resistance Transfer Among Enterococci. 2022, Front Mol Biosci 9:867136. DOI: https://doi.org/10.3389/fmolb.2022.867136 

  • M. Rotzinger, S. Tassoti, K. Zangger, Journal of Magnetic Resonance Open 2022, 12–13, 100073.