Structural and functional studies of apoptotic signaling Markus Rotzinger (PI Klaus Zangger): Using pure shift NMR to study the role of disordered proteins in the formation of stress granules Nikolina Todorović [...] Structural and functional investigation of the low-affinity IgE receptor CD23 Gregor Wirnsberger (PI Karl Gruber): Active site cavity and molecular dynamics analyses of mammalian α/β-hydrolase domain (ABHD) [...] Fuchs (PI Andreas Winkler): Molecular Mechanisms of LOV-regulated Diguanylate Cyclases Hermann Habacher (PI Tobias Madl): Structural and functional mechanisms in the intersection of p53 and Wnt signaling Amin
Biophysics of Membrane Proteins Membrane proteins represent about one third of all cellular proteins. They play key roles in the exchange of information and the transport of substances between and within [...] within cells. Due to their diverse tasks and the possibility of manipulating them from outside the cell, they are attractive targets for drug discovery. Because of their hydrophobic properties, membrane proteins [...] functionalization of new compounds using organic synthetic chemistry to produce nanodiscs with improved properties; development and application of biophysical methods to study the properties of proteins and
reactions. We are part of the Institute of Biochemistry at the Graz University of Technology, the initiative Integrative Structural Biology and Biophysics and within the framework of BioTechMed Graz. Principle [...] spectrophotometers to detect the desired activities. We are going to use fluorescence-activated-cell sorting (FACS) to screen libraries and evolve the designs further. The structures of the gained enzymes will [...] young interdisciplinary research group focuses on the design of enzymes possessing different selectivities than seen in nature. For this we use state-of-the-art computational protein design software like
PhD Projects Modulation of TRPC1/3/6 via photoactivable drugs for the regulation of pulmonary vascular tone Supervisor: Andrea Olschewski TRPML1 in Lysosome-Mitochondria Crosstalk during Cancer Energy [...] Gottschalk The role of TRPC6 channels in allergic airway inflammation Supervisor: Bernadette Bacsa Role of TRPC- BK channel axis in Regulating Calcium Influx and Functional Polarization of Macrophages [...] kolowski Computational modeling of TRPC channels in the heart Supervisor: Jordi Heijman TRP channels in cerebellum-like circuits Supervisor: Lukas Groschner Tuning the hippocampal calcium signals — how
immune system present mitochondrial decline with age. To investigate the consequences of the aging of the immune system, we have induced age-associated mitochondrial dysfunction prematurely in T cell. [...] Mittelbrunn, Ph.D., from Centro de Biologia Molecular Severo Ochoa, Madrid, will talk about “Immunometabolism at the crossroad between inflammation and aging”: As in many other cells and tissues, cells of the immune [...] members to a small buffet in the Rooftop Mensa from 6 to 9 p.m. Please register for the event until May 20, 2024. Childcare: BioTechMed-Graz is pleased to offer childcare for the Faculty Club from 4.30 p.m
2018 im Fach Kardiologie mit ihrer Arbeit “The role of endothelial function in the pathophysiology of cardiovascular disease: a translational journey from molecular mechanisms to clinical experience”. 2019 [...] ung im Fach Kardiologie ). 2010 schloss sie ebendort ihren PhD in Cardiovascular Sciences ab und erhielt für ihre Arbeit den Preis „Best PhD thesis on cardiovascular sciences“ von der Italienischen Ge [...] Mit Wirkung vom 01.04.2023 wurde Univ.-Prof. in Dr. in Elena Osto , PhD für das Fach „Physiologie und Pathophysiologie“ an den Lehrstuhl für Physiologie und Pathophysiologie der Medizinische Universität
Project: Bioresorbable materials in the field of implantology Supervisor: Univ.-Prof. Dr.med.univ. Dr.med.dent. Norbert Jakse Ivancic Gal Project: Mechanical properties of the L&H Titin wire compared to other [...] -Prof. Priv.-Doz. Dr.med.univ. Brigitte Wendl Kovacs Andreea Project:Influence of the redicality of pre-operative treatment of suspected dental foci on complications after solid organ transplantation Supervisor: [...] Dr.med.univ. Martin Lorenzoni Stursa Lea Katharina Project: Do different kinds of insertion guides improve the position of orthodontic miniscrews in comparison to conventional miniscrew insertion? Supervisor:
lesung von Prof. in Elena Osto "Endothelial function and the pathophysiology of cardiovascular disease: a translational journey from molecular mechanisms to clinical experience" [...] Universität Graz berufen. Mit Wirkung vom 01. April 2023 wurde Univ.-Prof. in Dr. in Elena Osto, PhD für das Fach „Physiologie und Pathophysiologie" an die Medizinische Universität Graz berufen. Den
from the Department of Pharmacology and Toxicology of the University of Graz presented her research in a plenary lecture at the end of the meeting. The event was a success, as highlighted by the number [...] and Spela Mandl from the Laboratory of Computer-Aided Molecular Design of the Division of Medicinal Chemistry for the best flash talk presentation. Congratulations to both of them! The OLRC Science Day was [...] sound setting, which facilitated the start of new collaborations and a constructive exchange of ideas between researchers of the Center. At the end of the meeting, a prize was awarded to Bruno Di Geronimo
Binding The PhD candidates study the intricate role of internal dynamics in regulation of ligand binding. The catalytic power of an enzyme, for example, depends on a significant reduction of the free energy [...] research projects. The members of the scientific advisory board are invited to join the yearly retreats to provide feedback for the students, the faculty and for improvement of the entire program. Their [...] Thus, the PhD candidates aim at studying the intricate role of dynamics at the lipid membrane-protein interface. Sandro Keller Georg Pabst Tea Pavkov-Keller Transient biomolecular interactions PhD candidates
