Forschung Gottfried Schatz Forschungszentrum

Forschungsschwerpunkt Stoffwechsel

Teamleiterin: Brigitte Pelzmann

Fokus: Erfoschung der Rolle von G-Protein-aktivierten K+-Ionen-Kanälen für die Manifestation von Krebsmerkmalen. Entstehung und Weiterleitung von kardialer Erregung im normalen und erkrankten Herzen (z.B. Sepsis, Vorhofflimmern). Implementierung innovativer lichtgesteuerter organischer optoelektronischer Geräte zur Behandlung von Behinderungen, die durch traumatische Hirnverletzungen verursacht wurden.

Vernetzung: Das Forschungsteam arbeitet eng mit dem Lehrstuhl für Biophysik zusammen: Helmut Ahammer (nonlinear analyses of temporal variabilities in beat-to-beat behavior of sinus node, long-range correlations in temporal signals); Gernot Plank (simulation of cardiac arrhythmogenesis at the tissue/organ level); sowie mit dem Lehrstuhl für Molekularbiologie und Biochemie: Eva Bernhart and Saša Frank (HDL particles and cardiac electrophysiology). Weitere Kooperationen bestehen mit dem Lehrstuhl Physiologische Chemie: Seth Hallström (oxLDL and cardiac electrophysiology) und der Klinischen Abteilung für Onkologie: Thomas Bauernhofer (breast cancer).

 

Projekte

Molecular Mechanisms of Heart Rate Variability in Sepsis

Susanne Scherübel-Posch

  • Sepsis refers to a wide spectrum of illness ranging from systemic infection to multiple organ dysfunction syndrome and death and its early recognition is therefore of great significance. Reduction of heart rate variability (HRV) has been suggested as a reliable prognostic marker for severe infection. It is mainly attributed to dynamic changes of autonomic inputs on ion channels in the sinoatrial node (SAN). But a certain degree of beat to beat variability (BBV) is inherently present at the level of SAN cells. We aim to reveal the molecular mechanisms of reduced BBV in sepsis using SAN-tissue/cells thereby opening new avenues to initiate therapeutic intervention at the earliest possible stage.
  • Laufzeit: 2019-2023
  • Gefördert durch: FWF
  • Projektpartner*innen: Helmut Ahammer (Med Uni Graz), Matteo Mangoni (Institut Génomique Functionelle, Montpellier, France), Nathan Dascal (Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel).

LOGOS-TBI: Light-controlled organic semiconductor implants in SHT

Susanne Scherübel-Posch

  • Traumatic Brain Injury (TBI) is a leading cause of death and disability, particularly among young adults. Light-driven neuron activation, an emerging field with a broad range of applications is viewed as a promising alternative approach to pharmacological interventions. To allow the implementation of innovative light-controlled organic optoelectronic devices in the treatment of traumatic brain injury-induced disabilities we are concerned with the establishment of stimulation parameters based on intracellular electrophysiological recordings and Ca2+ imaging for a safe and efficient activation of neurons via photocapacitive structures that convert light pulses into surface charging.
  • Laufzeit: 2019-2023
  • Gefördert durch: FWF
  • Projektpartner*innen: Muammer Üçal (Project coordinator, Med Uni Graz), Karin Kornmüller (Med Uni Graz), Theresa Rienmüller (TU Graz)

Lehrstuhl für Biophysik

Univ.-Doz.in Mag.a Dr.in
Brigitte Pelzmann  
T: +43 316 385 71525