Eight established research teams at four Austrian universities are studying lipid hydrolases, which are key enzymes for cell growth and proliferation, cellular signal transduction, and energy metabolism. Therefore, dysfunctions of these lipid hydrolases are often causes of many metabolic diseases. In the second funding period, the lipid hydrolases newly discovered in the first funding period will be characterized in detail. In the second funding period, the lipid hydrolases newly discovered in the first funding period will be characterized in detail. The better we understand the complex reaction processes of fat degradation, the easier it will be to decipher the causes of metabolic diseases and to find new treatment strategies. All research teams involved in the SFB have full access to six technology platforms to understand the structure, function and physiological relevance of lipid hydrolases. In this way, the SFB Lipid Hydrolysis aims to contribute to the elucidation of disease mechanisms and the development of new, innovative treatment strategies.