PI: Herbert Strobl
Focus: The system of mononuclear phagocytes and dendritic cells (DC) plays an important role in the recognition and defense against microbes and enables the induction of antigen-specific T cell immune responses. Precursors of these cells migrate into normal and diseased tissues, and the microenvironment in these tissues plays an important role in the differentiation and function of these cells. Using human models, immunohistochemistry of patients, and murine models, we aim to understand how individual signaling pathways in DCs control immunity, immune tolerance, and immune evasion. We are also investigating the mechanisms of differentiation of these cells.
Networking: In addition to collaborations within the Division of Immunology on DC: T cell interactions with Stefano Angiari and Johannes Fessler and on nutritional factors with Sandra Holasek, we collaborate closely with Armin Zebisch on miRNAs in myelopoiesis and DC differentiation and with Peter Wolf on DCs in psoriasis. Further cooperation on DC function exists with Maria Sibilia and Georg Stary (Medical University of Vienna) and Stefan Schild (University of Graz). We also collaborate with Jose da Silva (USA) on the role of miRNA 424/503 in DC differentiation.
