Forschung Gottfried Schatz Forschungszentrum

Research Focus: Reproduction, pregnancy and regeneration

PI: Thomas Kroneis

Focus: During most, if not all, pregnancies, there is a mutual exchange of cells between mother and child. These microchimeric cells can reside in the host body for decades. The function of this phenomenon has not been understood yet, although - or because - microchimeric cells are associated with processes as diverse cancer, autoimmune diseases, pregnancy disorders, tissue regeneration. Thus, our current projects focus on investigating how the microchimeric cells can transmigrate into the other body and in which tissues/ organs they may settle down.

Network: In our research we cooperate with Gerald Höfler, Irene Speicher (Diagnostics and Research Institute for Pathology), Herbert Fluhr, Philipp Klaritsch (Department of Obstetrics and Gynaecology). Internationally, we work in a Microchimerism Consortium together with Amy Boddy (University of California Santa Barbara), Henderson Cleaves (Blue Marble Space Institute of Science/Tokyo Technical University), Michael Eikmans (Dept. of Immunology, Leiden University Medical Center), and Frank Schildberg (Clinic for orthopedics and trauma surgery, University Hospital Bonn.


    We all are Multitudes: We All Are Multitudes: the Microchimerism, Human Health and Evolution Project

    • The origin and function of microchimerism are still not clear. In this project we investigate two possible ways maternal cells might transmigrate into the child, where these cells end up and in which biological processes they are embedded.
    • Duration: 2021-2024
    • Funded by: John Templeton Foundation

    Circulating tumor cells in breast cancer

    • The analysis of rare cells is a challenge in the field of single cell analysis. In this project we investigate the impact of single-cell RNA sequencing and its contribution to the field.
    • Duration: 2013-2018
    • Funded by: FWF, The Swedish Governmental Agency for Innovation Systems

    Single cell analysis in forensic medicine

    • In some cases, sperm analysis can be used for forensic investigations. In this project we are investigating to what extent individual sperm can be used for the identification of suspects.
    • Duration: 2010-2011
    • Funded by: County of Styria

    Division of Cell Biology, Histology and Embryology

    Priv.-Doz. Dipl.-Ing. Dr.
    Thomas Kroneis 
    T: +43 316 385 71904

    Dem Phänomen des Mikrochimärismus auf der Spur.