PI: Rudolf Schicho
Focus: The group focuses on the role of cannabinoid and prostaglandin receptors in models of intestinal inflammation, and of colon and lung cancer. Immune cells are integral part of the inflamed intestinal mucosa and the tumor microenvironment. The behavior of immune cells in this environment is regulated by these receptors and their endogenous ligands, the endocannabinoids and prostaglandins. Pharmacological manipulation of these receptors, therefore, critically influence tumorigenesis and inflammation.
Network: With regard to colon and lung cancer models, the research team closely cooperates with the group of Julia Kargl from the Division of Pharmacology. To investigate immune cell functions in eosinophilic esophagitis, a collaboration with the group of Eva Sturm from the Division of Pharmacology has been established. Collaborations also exist with Christoph Högenauer and Franziska Durchschein from the Department of Gastroenterology and Hepatology of the Medical University of Graz.