Otto Loewi Forschungszentrum

Research focus: Inflammation, autoimmunity and cancer

PI: Magdalena Grill

Focus: Our research group is dedicated to understanding the complex interplay between inflammation, tissue repair, and disease progression. A temporary alteration in cell phenotype is a natural response to injury and inflammatory stimuli, often leading to the resolution of inflammation and tissue repair. However, when these changes become persistent, they can disrupt tissue integrity and function, contributing to chronic inflammation, disease progression and even tumor development. We aim to identify and characterize inflammation associated, long lasting changes in tissue-resident, non-hämatopoietic cells, with a particular focus on fibroblasts, endothelial cells, and astrocytes.

Network: We collaborate with various groups internally at the Medical University of Graz, as well as nationally and internationally. The Division of Phoniatrics, University Department for Ear, Nose and Throat Medicine, and the Diagnostic and Research Institute for Human Genetics, both Med Uni Graz, are involved in current projects. We also maintain contact and exchange information with the Division of Pharmacology, Med Uni Graz, the Diagnostic and Research Institute for Pathology, Med Uni Graz, the Department of Neurology, Med Uni Vienna, the Institute for Pathophysiology and Allergy Research, Med Uni Vienna, and the School of Life and Environmental Sciences, University of Sydney, Australia.

Projects

Role of epigenetics and differential cytokine response in vocal fold fibroblasts of Reinke’s edema patients (FWF grant P 36067)

  • Reinke’s edema (RE), a benign lesion of the vocal folds, leads to a hoarse, deep voice and difficulties breathing. Current treatment options cannot result in permanent recovery. We aim to investigate differential cytokine responses and DNA methylation of RE fibroblasts and determine functional consequences.
  • Project duration: 2023-2027
  • Funding: FWF

Cellular localization of Sbno2/SBNO2 in solid tumors and cardiovascular tissue

  • Interleukin (IL)-6 is a well-known inflammatory cytokine, and increased expression correlates with adverse outcome of chronic diseases. The IL-6-regulated gene Sbno2 has recently been associated with cancer and chronic cardiovascular disease, which will be further elucidated.
  • Project duration: ongoing
  • Funding: Kulturamt Stadt Graz

Division of Physiology & Pathophysiology

Magdalena Grill  

Team

Former Members

  • Haas Sara Alena