Otto Loewi Forschungszentrum

Research focus: Inflammation, autoimmunity and cancer

PI: Stefano Angiari

Focus: Using a multidisciplinary approach (in vitro primary T cell cultures, biochemical assays, protein and gene expression analysis and in vivo disease models), we explore the complex role of T cells in inflammation and autoimmunity. We study all aspects of T cell biology, with a particular focus on the metabolic regulation of T cell responses. In addition, our main goal is to translate our results into questions relevant to human medicine, and to investigate how T cells influence the induction, development and severity of inflammatory and autoimmune diseases in humans.

Network: We are currently cooperating with international research partners from Ireland and Italy. In parallel, we are establishing new collaborations with clinicians and researchers at the Medical University of Graz.


Regulation of T cell function by extracellular metabolites

  • During inflammatory reactions, several metabolites can accumulate in the blood or in the inflamed tissue, either due to active secretion by local tissue/tumour cells and activated leukocytes, or due to cell necrosis caused by tissue damage. T cells express multiple transporters/receptors for these metabolites. We are investigating how extracellular metabolites affect T cell function, with the overall goal of identifying surface receptors or transporters that can specifically be targeted to inhibit T cell pathogenicity.
  • Duration: ongoing
  • Funded by: Med Uni Graz, Worldwide Cancer Research
  • Project partners: Julia Kargl, Otto Loewi Research Center, Division of Pharmacology, Med Uni Graz - Philipp Jost, Division of Oncology, Med Uni Graz

Alteration of leukocyte metabolism in autoimmune diseases

  • Several studies identified differences in the metabolic profile of circulating immune cells between healthy individuals and patients with inflammatory and autoimmune diseases. Alterations in the expression of nutrient transporters or metabolic enzymes in leukocytes, as well as their overall metabolic activity, may underline disease onset or impact disease progression and severity. By analysing clinical samples from patients with autoimmune diseases, we are evaluating the potential of signalling and metabolic mediators as biomarkers of disease activity in such life-threatening conditions.
  • Duration: ongoing
  • Funded by: Med Uni Graz, ÖMSFG, Kulturamt der Stadt Graz
  • Project partners: Michael Khalil, Division of General Neurology, Med Uni Graz, Johannes Fessler, Otto Loewi Research Center, Division of Immunology, Med Uni Graz

Division of Immunology

Stefano Angiari, PhD
T: +43 316 385 71172



Former Members:

  • Meyer Anna-Lena
  • Janjetovic Milica
  • Mori Elisabetta, Gastdoktorandin (Erasmus+)
  • Arishabhas Tantibhadrasapa, Gastdoktorandin (Erasmus+)
Forschungsteam von Stefano Angiari